SHERP

Graves 질환에서 억제 T임파구의 동태에 관한 연구
Studies on Suppressor T Lymphocytes in Graves' Disease

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Authors
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Issue Date
1984-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1984;25(4):527-539
Abstract
For the evaluation of suppressor T lymphocytes in
peripheral hlood in patients with Graves' disease, the
authors performed numerical count of T lymphocytes
and its suhsets by monoclonal antibody (Pan T: OKT
3' cells, Helper T: OKT 4+ cells, Suppressor T:
OKT Rc cells) and function test using suppressor cell
removal index (SCRI) , in 33 cases of normal control
and in 47 cases of Graves' disease patients.
In addition, antimicrosomal antibody (AMA) and
'lntithyroglobulin antibody (ATA) tests were also
performed by tanned red cell hemagglutination test
kits in serum to evaluate correlationship with SCRI.
The results were as follows:
L Suppressor cell removal index (SCRI) in untre'
lted hyperthyroid group cr. 84±L 04), euthyroid on
treatment group (2. 08±L 12) and euthyroid in remission
group (L 71±O. 57) were significantly lower
than normal control group (3. 09±L 26) (p<O.01).
The impairment of suppressor cell functions in
Graves’ disease patients were still observed when
patient became euthyroid by treatment with antithyroid
<!rugs.
2. Suppressor T lymphocyte counts in percentage
in untreated hyperthyroid group (25.81 ±4. 64) and
euthyroid on treatment group (24. 67±3. 44) were
significantly lower than normal control group (29.12
±4.57) (hyperthyroid group: p<0.02, euthyroid on
treatment group: p<O.01), however, no significant
<!ifferences were observed in euthyroid patient group
in remission state
3. No correlationship was observed between SCRI
and AMA titer (r=-0.16).
4. No correlationship was observed between SCRI
and ATA titer (r=-0.24),
5. No correlationship ₩a s observed between SCRI
and T 3 RIA concentration in serum of Graves' disease
patients.
6. No correlationship was observed between SCRI
and OKT 8+ cell percentage (r=0.21), but if distribution
of patients were divided into 4 groups by
SCRI 3. 09(mean in normal control group) and OKT
8+ cells 29.1296 (mean in normal control group) ,
68.296 of patients were distributed on lower SCRI
and lower OKT 8+ cells group and 97.896 of
patients were distributed on lower SCRI or lower
OKT 8+ cells group. Number of lower SCRI group
(88.790) was more than number of lower OKT8 •
cells group (77. 396).
Above data suggested that in Graves' disease, function
and numerical count of suppressor T lymphocytes
were significantly reduced than normal control ,
especially in function.
The treated patients did not show improved suppressor
cell function compared with untreated patients.
Lowered suppressor cell function in Graves' disease
might be a constitutional character based on an inhe·
rited abnormality specific for the disease population.
Language
Korean
URI
http://hdl.handle.net/10371/9606
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.4 (1984)
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