NKT cells play critical roles in the induction of oral tolerance by inducing regulatory T cells producing IL-10 and transforming growth factor beta, and by clonally deleting antigen-specific T cells

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Kim, Hyun Jung; Hwang, Su Jin; Kim, Byoung Kwon; Jung, Kyeong Cheon; Chung, Doo Hyun
Issue Date
Blackwell Publishing
Immunology 2006; 118:101-11
clonal deletionnatural killer T cellsoral toleranceregulatory T cells
Oral tolerance is the systemic unresponsiveness induced by orally administered
proteins. To explore the roles of natural killer T (NKT) cells in
oral tolerance, we induced oral tolerance to ovalbumin (OVA) in NKT
cell-deficient mice. In CD1d–/– mice, the induction of tolerance to orally
administered high- or low-dose OVA was impaired. Dendritic cells (DCs)
in the Peyer’s patches (PPs) of CD1d–/– mice fed OVA showed high
expression of major histocompatibility complex (MHC) class II and B7
molecules, whereas DCs of control mice fed OVA expressed low levels of
these molecules. The adoptive transfer of NKT cells restored oral tolerance
and induction of tolerogenic DCs in the PPs and spleens of CD1d–/–
mice. Moreover, interleukin (IL)-10 and transforming growth factor
(TGF)-b1 production in vitro were reduced in cells from the spleen and
PPs of CD1d–/– mice compared with those of control mice fed OVA. The
numbers of OVA-specific CD4+ KJ1-26+ T cells were significantly reduced
in the PPs and spleens of DO11 10 mice fed OVA. In contrast, OVA-specific
CD4+ KJ1-26+ T cells were not deleted in the PPs or spleens of
DO11 10 CD1d–/– mice. In conclusion, NKT cells were found to play an
indispensable role in oral tolerance by inducing regulatory T cells, and
clonally deleting antigen-specific CD4+ T cells.
0019-2805 (print)
1365-2567 (online)
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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