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Decreased frontal white-matter integrity in abstinent methamphetamine abusers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Ain | - |
dc.contributor.author | Lyoo, In Kyoon | - |
dc.contributor.author | Kim, Seog Ju | - |
dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Bae, Soojeong C. | - |
dc.contributor.author | Sung, Young Hoon | - |
dc.contributor.author | Sim, Minyoung E. | - |
dc.contributor.author | Song, In Chan | - |
dc.contributor.author | Kim, Jihyun | - |
dc.contributor.author | Chang, Kee Hyun | - |
dc.date.accessioned | 2009-09-28T09:37:36Z | - |
dc.date.available | 2009-09-28T09:37:36Z | - |
dc.date.issued | 2006-12-07 | - |
dc.identifier.citation | International Journal of Neuropsychopharmacology 10, 765-775 | en |
dc.identifier.issn | 1461-1457 (print) | - |
dc.identifier.issn | 1469-5111 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/9944 | - |
dc.description.abstract | This study explored differences in frontal white-matter (WM) integrity between methamphetamine (MA)
abusers and healthy comparison subjects using diffusion tensor imaging (DTI). Fractional anisotropy (FA) values, which indicate WM integrity, were calculated for regions-of-interest in frontal WM on diffusion tensor images of 32 MA abusers and 30 healthy comparison subjects. Frontal executive functions were also assessed by the Wisconsin Card Sorting test (WCST). MA abusers had significantly lower FA values in bilateral frontal WM at the anterior commissure–posterior commissure (AC–PC) plane and the right frontal WM 5 mm above the AC–PC plane relative to healthy comparison subjects. MA abusers had more total, perseveration and non-perseveration errors in the WCST relative to healthy comparison subjects. FA values of the right frontal WM 5 mm above the AC–PC plane negatively correlated with the number of total and non-perseveration errors in the WCST in MA abusers. In the sub-analysis for gender differences, lower FA values in frontalWMand more errors in the WCST were found only in male MA abusers, not in female MA abusers, relative to comparison subjects of the respective gender. We report that frontal WM integrity of MA abusers is compromised. This finding may also be related to impairment in frontal executive function. In addition, the neurotoxic effect of MA on frontal WM may be less prominent in women than in men, possibly due to oestrogens neuroprotective effect. | en |
dc.description.sponsorship | This research was supported by a grant (60%)
(M103KV010022-06K2201-02210) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, the Republic of Korea (I.K.L.), and in part by grants from the National Institute on Drug Abuse (DA09448: P.F.R. ; DA09448-09S1: I.K.L and P.F.R.) and the National Institute of Mental Health (MH58681: P.F.R.). | en |
dc.language.iso | en | - |
dc.publisher | Cambridge University Press | en |
dc.subject | Diffusion tensor | en |
dc.subject | frontal lobe | en |
dc.subject | methamphetamine | en |
dc.subject | white matter | en |
dc.title | Decreased frontal white-matter integrity in abstinent methamphetamine abusers | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정아인 | - |
dc.contributor.AlternativeAuthor | 류인균 | - |
dc.contributor.AlternativeAuthor | 김성주 | - |
dc.contributor.AlternativeAuthor | 황재욱 | - |
dc.contributor.AlternativeAuthor | 배수정 | - |
dc.contributor.AlternativeAuthor | 성영훈 | - |
dc.contributor.AlternativeAuthor | 심민영 | - |
dc.contributor.AlternativeAuthor | 김지현 | - |
dc.contributor.AlternativeAuthor | 장기현 | - |
dc.identifier.doi | 10.1017/S1461145706007395 | - |
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