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Showing results 1 to 4 of 4

Issue DateTitle / Author(s) / CitationFileAltmetrics
2019-11
Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

Asaumi, Ryuta; Menzel, Karsten; Lee, Wooin; Nunoya, Ken-Ichi; Imawaka, Haruo; Kusuhara, Hiroyuki; Sugiyama, Yuichi

CPT: Pharmacometrics and Systems Pharmacology, Vol.8 No.11, pp.845-857

DOI
2020-11
Phase 0/microdosing approaches: time for mainstream application in drug development?

Burt, Tal; Young, Graeme; Lee, Wooin; Kusuhara, Hiroyuki; Langer, Oliver; Rowland, Malcolm; Sugiyama, Yuichi

Nature Reviews Drug Discovery, Vol.19 No.11, pp.801-818

DOI
2020-11
Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs
DOI
2021-01
Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes
DOI
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