서울대학교 중앙도서관
S-Space 소개
My S-Space
로그인이 필요합니다.
Login

S-Space

Browse

Author

Jump to a point in the index
Or type in a year

  • Sort by
  • In order
  • Results/Page
  • Authors/record

Showing results 1 to 16 of 16

Issue DateTitle / Author(s) / CitationFileAltmetrics
2018-03
Comprehensive PBPK model of rifampicin for quantitative prediction of complex drug-drug interactions: CYP3A/2C9 induction and OATP inhibition effects

Asaumi, Ryuta; Toshimoto, Kota; Tobe, Yoshifusa; Hashizume, Kenta; Ken-ichi Nunoya; Imawaka, Haruo; Lee, Woo In; Sugiyama, Yuichi

CPT: Pharmacometrics and Systems Pharmacology, Vol.7 No.3, pp.186-196

DOI
2018-05
Physiologically based pharmacokinetic modeling of bosentan identifies the saturable hepatic uptake as a major contributor to its nonlinear pharmacokinetics
DOI
2018-07
Application of PBPK modeling and virtual clinical study approaches to predict the outcomes of CYP2D6 genotype-guided dosing of tamoxifen

Nakamura, Toshimichi; Toshimoto, Kota; Lee, Wooin; Imamura, Chiyo K.; Tanigawara, Yusuke; Sugiyama, Yuichi

CPT: Pharmacometrics and Systems Pharmacology, Vol.7 No.7, pp.474-482

DOI
2019-06
Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine

Nishiyama, Kotaro; Toshimoto, Kota; Lee, Wooin; Ishiguro, Naoki; Bister, Bojan; Sugiyama, Yuichi

CPT: Pharmacometrics and Systems Pharmacology, Vol.8 No.6, pp.396-406

DOI
2019-11
Comparative and quantitative assessment on statin efficacy and safety: insights into inter-statin and inter-individual variability via dose- and exposure-response relationships

Iwaki, Yuki; Lee, Wooin; Sugiyama, Yuichi

Expert Opinion on Drug Metabolism and Toxicology, Vol.15 No.11, pp.897-911

DOI
2019-11
Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

Asaumi, Ryuta; Menzel, Karsten; Lee, Wooin; Nunoya, Ken-Ichi; Imawaka, Haruo; Kusuhara, Hiroyuki; Sugiyama, Yuichi

CPT: Pharmacometrics and Systems Pharmacology, Vol.8 No.11, pp.845-857

DOI
2020-10
Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs
DOI
2020-11
Phase 0/microdosing approaches: time for mainstream application in drug development?

Burt, Tal; Young, Graeme; Lee, Wooin; Kusuhara, Hiroyuki; Langer, Oliver; Rowland, Malcolm; Sugiyama, Yuichi

Nature Reviews Drug Discovery, Vol.19 No.11, pp.801-818

DOI
2020-12
Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion-transporting polypeptides

Lee, Wooin; Ha, Jeong-min; Sugiyama, Yuichi

Journal of Biological Chemistry, Vol.295 No.50, pp.17349-17364

DOI
2021-01
Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B

Park, Ji Eun; Shitara, Yoshihisa; Lee, Wooin; Morita, Shigemichi; Sahi, Jasminder; Toshimoto, Kota; Sugiyama, Yuichi

Journal of Pharmaceutical Sciences, Vol.110 No.1, pp.517-528

DOI
2021-01
A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

Tomaru, Atsuko; Toshimoto, Kota; Lee, Wooin; Ishigame, Keiko; Sugiyama, Yuichi

Journal of Pharmaceutical Sciences, Vol.110 No.1, pp.510-516

DOI
2021-01
Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes
DOI
2021-01
Transient, Tunable Expression of NTCP and BSEP in MDCKII Cells for Kinetic Delineation of the Rate-Determining Process and Inhibitory Effects of Rifampicin in Hepatobiliary Transport of Taurocholate

Ito, Sumito; Lee, Wooin; Park, Ji Eun; Yasunaga, Masa; Mori, Ayano; Ohtsuki, Sumio; Sugiyama, Yuichi

Journal of Pharmaceutical Sciences, Vol.110 No.1, pp.365-375

DOI
2021-04
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy

Koyama, Satoshi; Toshimoto, Kota; Lee, Wooin; Aoki, Yasunori; Sugiyama, Yuichi

Drug Metabolism and Disposition, Vol.49 No.4, pp.298-304

DOI
2022-01
Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo

Miyauchi, Seiji; Kim, Soo-Jin; Lee, Wooin; Sugiyama, Yuichi

Pharmacology and Therapeutics, Vol.229, p. 107938

DOI
2022-05
Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

Izumi, Saki; Nozaki, Yoshitane; Lee, Wooin; Sugiyama, Yuichi

Drug Metabolism and Disposition, Vol.50 No.5, pp.541-551

DOI
1