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Prediction of treatment outcome in chronic hepatitis C patients based on early viral dynamics during high-dose induction interferon and ribavirin therapy

Cited 8 time in Web of Science Cited 7 time in Scopus
Authors
Kim, Tae Hun; Kim, Kyung A; Lim, Young Seok; Gwak, Geum-Youn; Yoon, Jung-Hwan; Kang, Gyeong Hoon; Lee, Hyo-Suk
Issue Date
2005-05-28
Publisher
S. Karger AG
Citation
Intervirology 2005;48(4):230-238.
Keywords
AdultAntiviral Agents/administration & dosage/*therapeutic useDrug Administration ScheduleDrug Therapy, CombinationFemaleHepacivirus/*drug effects/physiologyHepatitis C, Chronic/*drug therapy/virologyHumansInterferon Alfa-2a/administration & dosage/*therapeutic useMaleMiddle AgedPredictive Value of TestsRNA, Viral/bloodRibavirin/administration & dosage/*therapeutic useTreatment Outcome*Viral Load
Abstract
OBJECTIVE: In chronic hepatitis C, early viral load decline after interferon administration is dose dependent and reflects the intrinsic viral susceptibility to the antiviral action of interferon. We examined whether the augmented suppression of susceptible viral loads by high-dose induction interferon could possibly discriminate responsive patients from non-responsive patients at an early stage of treatment. METHODS: Fifty-nine chronic hepatitis C patients were randomly allocated to receive one of two treatment regimens; 3 MU interferon three times weekly plus ribavirin 1,000 mg/day for 24 weeks in the CR group (n = 30), and the same regimen as in the CR group except 10 MU interferon daily for the first week in the HR group (n = 29). Changes in viral loads during the first week of treatment were analyzed in terms of sustained virological response (SVR). RESULTS: The positive predictive values of undetectable (<100 IU/ml) or low serum HCV RNA (<2,000 IU/ml) after 1 week of treatment for SVR were 100% in both treatment groups, whereas the negative predictive values of the low viral titer were 91% in the HR group and 70% in the CR group. CONCLUSION: One-week virological response to high-dose induction interferon/ribavirin combination therapy is more predictive of SVR than conventional combination therapy in chronic hepatitis C.
ISSN
0300-5526 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15920347

http://hdl.handle.net/10371/10014
DOI
https://doi.org/10.1159/000084600
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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