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Age-related changes in microvillar cells of rat olfactory epithelium

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Kwon, Bum Sun; Kim, Min Kyu; Kim, Woo Ho; Pyo, Jung-Soo; Cheon, Young Hee; Cha, Choong Ik; Nam, Seon Young; Baik, Tai-Kyoung; Lee, Byung Lan
Issue Date
2005-03-19
Publisher
Elsevier
Citation
Neurosci. Lett. 378 (2005) 65-69.
Keywords
Age FactorsAging/*physiologyAnimalsCell Count/methodsCell SizeEpithelial Cells/physiology/*ultrastructureGlial Fibrillary Acidic Protein/metabolismHypertrophy/pathologyImmunohistochemistry/methodsMaleMicroscopy, Electron, Transmission/methodsMicrovilli/ultrastructureOlfactory Mucosa/metabolism/*physiology/ultrastructureProliferating Cell Nuclear Antigen/metabolismRatsRats, Sprague-Dawley
Abstract
The nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained MVCs with marked hypertrophy and swollen end-feet, which reached the basement membrane. Such MVC features were not observed in the young OE. These MVC changes were more conspicuous in proximity to severely degenerated olfactory receptor neurons (ORNs) and supporting cells. The ratio of the number of MVCs to that of supporting cells increased with aging; however, MVCs in the aged OE were not proliferating cell nuclear antigen-immunoreactive. In addition, the total cell population was decreased in the aged OE. Thus, our results suggest that MVCs are non-neuronal and that they are more resistant to aging compared to ORNs and supporting cells.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15774259

http://hdl.handle.net/10371/10022
DOI
https://doi.org/10.1016/j.neulet.2004.11.094
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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