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Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji Hun | - |
dc.contributor.author | Kim, Min Kyu | - |
dc.contributor.author | Lee, Hee Eun | - |
dc.contributor.author | Cho, Sung Jin | - |
dc.contributor.author | Cho, Yu Jin | - |
dc.contributor.author | Lee, Byung Lan | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Nam, Seon Young | - |
dc.contributor.author | Lee, Jae-Seon | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.date.accessioned | 2009-10-04T23:39:48Z | - |
dc.date.available | 2009-10-04T23:39:48Z | - |
dc.date.issued | 2007-05-11 | - |
dc.identifier.citation | Mod Pathol 2007;20(8):835-842. | en |
dc.identifier.issn | 0893-3952 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17491598 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10039 | - |
dc.description.abstract | Increased phosphorylation of FOXO1A, a FOXO transcription factor, has been implicated in several human cancers; however, it has not been studied in the gastric cancer to date. To determine the status of pFOXO1A expression in human gastric cancers and to determine its relationship with other tumor-associated proteins, we performed immunohistochemical staining on tissue array slides containing 272 human gastric carcinoma specimens. In non-neoplastic gastric mucosa, the expression of pFOXO1A was observed primarily in cells in the proliferative zone and in areas of intestinal metaplasia. In gastric carcinomas, the expression of pFOXO1A was observed in 230 (84.6%) out of 272 cases examined, and was positively correlated with the Ki-67-labeling index (P=0.026). The expression of pFOXO1A was higher in the early stages of pTNM (P<0.001), and was inversely correlated with the intestinal type by Lauren's classification (P=0.001), lymphatic invasion (P=0.017) and lymph node metastasis (P<0.001). Moreover, the expression of pFOXO1A was correlated with a longer patient survival (P=0.004). In addition, the expression of pFOXO1A was correlated with that of pAKT1 (P<0.001), PTEN (P=0.009), CDKN2A (P=0.012), APC (P=0.048), SMAD4 (P<0.001), CD82 (P=0.011), and BCL2 (P=0.011). In conclusion, our results showed that the expression of pFOXO1A is a frequent and early event in gastric tumorigenesis and that there is a significant correlation between pFOXO1A and better prognosis. Thus, our data suggest that the expression of pFOXO1A may serve as a valuable prognostic variable in gastric carcinoma and have significant implications for the development and application of targeted therapy. | en |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | en |
dc.subject | Apoptosis | en |
dc.subject | Carcinoma/*chemistry/mortality/pathology/therapy | en |
dc.subject | Cell Differentiation | en |
dc.subject | Cell Proliferation | en |
dc.subject | Forkhead Transcription Factors/*analysis | en |
dc.subject | Glutathione S-Transferase pi/analysis | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Kaplan-Meiers Estimate | en |
dc.subject | Neoplasm Invasiveness | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Phosphorylation | en |
dc.subject | Prognosis | en |
dc.subject | Proportional Hazards Models | en |
dc.subject | Proto-Oncogene Proteins c-akt/analysis | en |
dc.subject | Proto-Oncogene Proteins c-bcl-2/analysis | en |
dc.subject | Stomach Neoplasms/*chemistry/mortality/pathology/therapy | en |
dc.subject | Superoxide Dismutase/analysis | en |
dc.subject | Tissue Array Analysis | en |
dc.subject | Treatment Outcome | en |
dc.subject | Tumor Markers, Biological/*analysis | en |
dc.subject | Tumor Suppressor Proteins/analysis | en |
dc.title | Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김지헌 | - |
dc.contributor.AlternativeAuthor | 김민규 | - |
dc.contributor.AlternativeAuthor | 이희은 | - |
dc.contributor.AlternativeAuthor | 조성진 | - |
dc.contributor.AlternativeAuthor | 조유진 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 남선영 | - |
dc.contributor.AlternativeAuthor | 이재선 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.identifier.doi | 10.1038/modpathol.3800789 | - |
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