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Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Jisun | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Moon, Hyeong-Gon | - |
dc.contributor.author | Ahn, Soo Kyung | - |
dc.contributor.author | Shin, Hee-Chul | - |
dc.contributor.author | You, Jee-Man | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Koo, Hye Ryoung | - |
dc.contributor.author | Chang, Jung Min | - |
dc.contributor.author | Cho, Nariya | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.date.accessioned | 2017-02-03T02:38:07Z | - |
dc.date.available | 2017-02-03T02:38:07Z | - |
dc.date.issued | 2012-07-06 | - |
dc.identifier.citation | Breast Cancer Research, 14(4):R102 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100408 | - |
dc.description | This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ko_KR |
dc.description.abstract | Abstract
Introduction Anti-estrogen therapy has been shown to reduce mammographic breast density (MD). We hypothesized that a short-term change in breast density may be a surrogate biomarker predicting response to adjuvant endocrine therapy (ET) in breast cancer. Methods We analyzed data for 1,065 estrogen receptor (ER)-positive breast cancer patients who underwent surgery between 2003 and 2006 and received at least 2 years of ET, including tamoxifen and aromatase inhibitors. MD was measured using Cumulus software 4.0 and expressed as a percentage. MD reduction (MDR) was defined as the absolute difference in MD of mammograms taken preoperatively and 8-20 months after the start of ET. Results At a median follow-up of 68.8 months, the overall breast cancer recurrence rate was 7.5% (80/1065). Mean MDR was 5.9% (range, -17.2% to 36.9%). Logistic regression analysis showed that age < 50 years, high preoperative MD, and long interval between start of ET to follow-up mammogram were significantly associated with larger MDR (p < 0.05). In a survival analysis, tumor size, lymph node positivity, high Ki-67 (≥ 10%), and low MDR were independent factors significantly associated with recurrence-free survival (p < 0.05). Compared with the group showing the greatest MDR (≥ 10%), the hazard ratios for MDRs of 5-10%, 0-5%, and < 0% were 1.33, 1.92, and 2.26, respectively. Conclusions MD change during short-term use of adjuvant ET was a significant predictor of long-term recurrence in women with ER-positive breast cancer. Effective treatment strategies are urgently needed in patients with low MDR despite about 1 year of ET. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김지선 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 문형곤 | - |
dc.contributor.AlternativeAuthor | 안수경 | - |
dc.contributor.AlternativeAuthor | 신희철 | - |
dc.contributor.AlternativeAuthor | 유지만 | - |
dc.contributor.AlternativeAuthor | 한새원 | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.contributor.AlternativeAuthor | 김태유 | - |
dc.contributor.AlternativeAuthor | 구혜령 | - |
dc.contributor.AlternativeAuthor | 장정민 | - |
dc.contributor.AlternativeAuthor | 조나리야 | - |
dc.contributor.AlternativeAuthor | 문우경 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.identifier.doi | 10.1186/bcr3221 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Kim et al.; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-29T03:04:34Z | - |
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