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Prognostic significance of loss of c-fos protein in gastric carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jin, Seon Pil | - |
dc.contributor.author | Kim, Ji Hun | - |
dc.contributor.author | Kim, Min A | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Lee, Hee Eun | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.date.accessioned | 2009-10-04T23:52:44Z | - |
dc.date.available | 2009-10-04T23:52:44Z | - |
dc.date.issued | 2007-12-26 | - |
dc.identifier.citation | Pathol Oncol Res 13(4):284-289, 2007 | en |
dc.identifier.issn | 1219-4956 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18158562 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10043 | - |
dc.description.abstract | c-fos was first identified as a viral oncoprotein, and has been studied in terms of its oncogenic function in tumorigenesis. Many experimental and clinical data indicated that c-fos expression plays a role in the progression of several types of carcinomas. However, some recent studies challenge this view as they indicate that c-fos has tumor suppressor activity. In the present study, we assessed c-fos protein expression in 625 consecutive gastric cancers immunohistochemically, and analyzed its relationship with clinicopathologic factors and survival. We found that a loss of c-fos expression is correlated with a more advanced stage, lymph node metastasis, lymphatic invasion and shorter survival, indicating that c-fos expression in gastric cancer cells is lost during progression and that this loss is associated with a poor prognosis. The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Carcinoma/metabolism/mortality/*pathology | en |
dc.subject | Disease Progression | en |
dc.subject | Prognosis | en |
dc.subject | Proto-Oncogene Proteins c-fos/*metabolism | en |
dc.subject | Survival Rate | en |
dc.subject | Stomach Neoplasms/metabolism/mortality/*pathology | en |
dc.title | Prognostic significance of loss of c-fos protein in gastric carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 진선필 | - |
dc.contributor.AlternativeAuthor | 김지헌 | - |
dc.contributor.AlternativeAuthor | 김민아 | - |
dc.contributor.AlternativeAuthor | 양한광 | - |
dc.contributor.AlternativeAuthor | 이희은 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
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