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Rg3-enriched ginseng extract ameliorates scopolamine-induced learning deficits in mice

Cited 11 time in Web of Science Cited 14 time in Scopus
Authors
Kim, Jiyoung; Shim, Jaesung; Lee, Siyoung; Cho, Woo-Hyun; Hong, Eunyoung; Lee, Jin Hee; Han, Jung-Soo; Lee, Hyong Joo; Lee, Ki Won
Issue Date
2016-02-18
Publisher
BioMed Central
Citation
BMC Complementary and Alternative Medicine, 16(1):66
Keywords
GinsengRg3ScopolamineMemoryAcetylcholinesteraseNF-κB
Description
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.
Abstract
Abstract

Background
Ginseng (Panax ginseng C.A. Meyer) has been used as a traditional herb in the treatment of many medical disorders. Ginsenosides, which are triterpene derivatives that contain sugar moieties, are the main pharmacological ingredients in ginseng. This study was designed to investigate the effect of ginsenoside Rg3-enriched ginseng extract (Rg3GE) on scopolamine-induced memory impairment in mice.


Methods
Rg3GE (50 and 100 mg/kg) were administered to C57BL/6 mice by oral gavage for 14 days (days 1–14). Memory impairment was induced by scopolamine (1 mg/kg, intraperitoneal injection) for 6 days (days 914). The Morris water maze test was used to assess hippocampus-dependent spatial memory. The effects of scopolamine with or without Rg3GE on acetylcholinesterase and nuclear factor-κB (NF-κB) in the hippocampus were also examined.


Results
Mice with scopolamine treatment alone showed impairments in the acquisition and retention of spatial memory. Mice that received Rg3GE and scopolamine showed no scopolamine-induced impairment in the acquisition of spatial memory. Oral administration of Rg3GE suppressed the scopolamine-mediated increase in acetylcholinesterase activity and stimulation of the NF-κB pathway (i.e., phosphorylation of p65) in the hippocampus.


Conclusion
These findings suggest that Rg3GE may stabilize scopolamine-induced memory deficits through the inhibition of acetylcholinesterase activity and NF-κB signaling in the hippocampus.
Language
English
URI
https://hdl.handle.net/10371/100443
DOI
https://doi.org/10.1186/s12906-016-1050-z
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Biomodulation (바이오모듈레이션전공)Journal Papers (저널논문_바이오모듈레이션전공)
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