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Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Soo Jung | - |
dc.contributor.author | Yoon, Soon Ho | - |
dc.contributor.author | Choi, Sun Mi | - |
dc.contributor.author | Lee, Jinwoo | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.date.accessioned | 2017-02-06T05:39:38Z | - |
dc.date.available | 2017-02-06T05:39:38Z | - |
dc.date.issued | 2017-01-05 | - |
dc.identifier.citation | BMC Pulmonary Medicine, 17(1):5 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100449 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background Patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, little is known about the association between body morphotype and progression of NTM-LD. The aim of this study was to elucidate predictors of NTM-LD progression, focusing on body morphotype and composition. Methods Data from patients with NTM-LD who participated in NTM cohort which started in 1 July 2011 were analyzed. Patients with more than 6months of follow up were included for analysis. NTM-LD progression was defined as clinician-initiated anti-NTM treatment, based on symptomatic and radiologic aggravation. Body morphotype and composition was measured at entry to the cohort using bioelectrical impedance analysis. Results NTM-LD progressed in 47 out of 150 patients with more than 6months of follow up. Patients with middle (adjusted hazard ratio [aHR], 2.758; 95% confidence interval [CI], 1.112–6.843) or lowest tertile (aHR, 3.084; 95% CI, 1.241–7.668) of abdominal fat ratio had a higher risk of disease progression compared with the highest tertile. Other predictors for disease progression were presence of cavity on chest computed tomography (aHR, 4.577; 95% CI, 2.364–8.861), and serum albumin level <3.5g/dL (aHR, 12.943; 95% CI, 2.588–64.718). Conclusions Progression of NTM-LD is associated with body composition. Lower abdominal fat ratio is an independent predictor of NTM-LD progression. Trial registration ClinicalTrials.gov, NCT01616745 Registered 25 March 2012 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Abdominal fat | ko_KR |
dc.subject | Anthropometry | ko_KR |
dc.subject | Body composition | ko_KR |
dc.subject | Nontuberculous mycobacteria | ko_KR |
dc.title | Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김수정 | - |
dc.contributor.AlternativeAuthor | 윤순호 | - |
dc.contributor.AlternativeAuthor | 최선미 | - |
dc.contributor.AlternativeAuthor | 이진우 | - |
dc.contributor.AlternativeAuthor | 이창훈 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 임재준 | - |
dc.identifier.doi | 10.1186/s12890-016-0349-3 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-01-06T10:01:55Z | - |
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