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A genome-wide Asian genetic map and ethnic comparison: The GENDISCAN study

DC Field Value Language
dc.contributor.authorJu, Young Seok-
dc.contributor.authorPark, Hansoo-
dc.contributor.authorLee, Mi Kyeong-
dc.contributor.authorKim, Jong-Il-
dc.contributor.authorSung, Joohon-
dc.contributor.authorCho, Sung-Il-
dc.contributor.authorSeo, Jeong-Sun-
dc.date.accessioned2017-02-07T00:37:21Z-
dc.date.available2017-03-17T16:39:19Z-
dc.date.issued2008-11-25-
dc.identifier.citationBMC Genomics, 9(1):554ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100463-
dc.descriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ko_KR
dc.description.abstractAbstract

Background
Genetic maps provide specific positions of genetic markers, which are required for performing genetic studies. Linkage analyses of Asian families have been performed with Caucasian genetic maps, since appropriate genetic maps of Asians were not available. Different ethnic groups may have different recombination rates as a result of genomic variations, which would generate misspecification of the genetic map and reduce the power of linkage analyses.


Results
We constructed the genetic map of a Mongolian population in Asia with CRIMAP software. This new map, called the GENDISCAN map, is based on genotype data collected from 1026 individuals of 73 large Mongolian families, and includes 1790 total and 1500 observable meioses. The GENDISCAN map provides sex-averaged and sex-specific genetic positions of 1039 microsatellite markers in Kosambi centimorgans (cM) with physical positions. We also determined 95% confidence intervals of genetic distances of the adjacent marker intervals.
Genetic lengths of the whole genome, chromosomes and adjacent marker intervals are compared with those of Rutgers Map v.2, which was constructed based on Caucasian populations (Centre d'Etudes du Polymorphisme Humain (CEPH) and Icelandic families) by mapping methods identical to those of the GENDISCAN map, CRIMAP software and the Kosambi map function. Mongolians showed approximately 1.9 fewer recombinations per meiosis than Caucasians. As a result, genetic lengths of the whole genome and chromosomes of the GENDISCAN map are shorter than those of Rutgers Map v.2. Thirty-eight marker intervals differed significantly between the Mongolian and Caucasian genetic maps.


Conclusion
The new GENDISCAN map is applicable to the genetic study of Asian populations. Differences in the genetic distances between the GENDISCAN and Caucasian maps could facilitate elucidation of genomic variations between different ethnic groups.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.titleA genome-wide Asian genetic map and ethnic comparison: The GENDISCAN studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor주영석-
dc.contributor.AlternativeAuthor박한수-
dc.contributor.AlternativeAuthor이미경-
dc.contributor.AlternativeAuthor김종일-
dc.contributor.AlternativeAuthor성주헌-
dc.contributor.AlternativeAuthor조성일-
dc.contributor.AlternativeAuthor서정선-
dc.identifier.doi10.1186/1471-2164-9-554-
dc.language.rfc3066en-
dc.rights.holderJu et al; licensee BioMed Central Ltd.-
dc.date.updated2017-01-06T10:03:44Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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