Publications
Detailed Information
Comprehensive identification of sexually dimorphic genes in diverse cattle tissues using RNA-seq
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Minseok | - |
dc.contributor.author | Caetano-Anolles, Kelsey | - |
dc.contributor.author | Rodriguez-Zas, Sandra | - |
dc.contributor.author | Ka, Sojeong | - |
dc.contributor.author | Jeong, Jin Young | - |
dc.contributor.author | Park, Sungkwon | - |
dc.contributor.author | Kim, Min Ji | - |
dc.contributor.author | Nho, Whan-Gook | - |
dc.contributor.author | Cho, Seoae | - |
dc.contributor.author | Kim, Heebal | - |
dc.contributor.author | Lee, Hyun-Jeong | - |
dc.date.accessioned | 2017-02-07T06:21:21Z | - |
dc.date.available | 2017-02-07T06:21:21Z | - |
dc.date.issued | 2016-01-27 | - |
dc.identifier.citation | BMC Genomics, 17(1):81 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100483 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background Molecular mechanisms associated with sexual dimorphism in cattle have not been well elucidated. Furthermore, as recent studies have implied that gene expression patterns are highly tissue specific, it is essential to investigate gene expression in a variety of tissues using RNA-seq. Here, we employed and compared two statistical methods, a simple two group test and Analysis of deviance (ANODEV), in order to investigate bovine sexually dimorphic genes in 40 RNA-seq samples distributed across two factors: sex and tissue. Results As a result, we detected 752 sexually dimorphic genes across tissues from two statistical approaches and identified strong tissue-specific patterns of gene expression. Additionally, significantly detected sex-related genes shared between two mammal species (cattle and rat) were identified using qRT-PCR. Conclusions Results of our analyses reveal that sexual dimorphism of metabolic tissues and pituitary gland in cattle involves various biological processes. Several differentially expressed genes between sexes in cattle and rat species are shared, but show tissue-specific patterns. Finally, we concluded that two distinct statistical approaches have their advantages and disadvantages in RNA-seq studies investigating multiple tissues. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | RNA-seq | ko_KR |
dc.subject | Sexual dimorphism | ko_KR |
dc.subject | Tissue-specific gene expression | ko_KR |
dc.subject | ANODEV | ko_KR |
dc.title | Comprehensive identification of sexually dimorphic genes in diverse cattle tissues using RNA-seq | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 서민석 | - |
dc.contributor.AlternativeAuthor | 가소정 | - |
dc.contributor.AlternativeAuthor | 정진영 | - |
dc.contributor.AlternativeAuthor | 박성권 | - |
dc.contributor.AlternativeAuthor | 김민지 | - |
dc.contributor.AlternativeAuthor | 노관국 | - |
dc.contributor.AlternativeAuthor | 조서애 | - |
dc.contributor.AlternativeAuthor | 김희발 | - |
dc.contributor.AlternativeAuthor | 이현정 | - |
dc.identifier.doi | 10.1186/s12864-016-2400-4 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Seo et al. | - |
dc.date.updated | 2017-01-06T10:07:31Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.