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Consideration of serum glucose levels during malignant mediastinal lymph node detection in non-small-cell lung cancer by FDG-PET
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, WON WOO | - |
dc.contributor.author | Chung, JIN-HAENG | - |
dc.contributor.author | Jang, SUNG-JUNE | - |
dc.contributor.author | Eo, JAE SEON | - |
dc.contributor.author | Park, SO YEON | - |
dc.contributor.author | Sung, SOOK WHAN | - |
dc.contributor.author | So, YOUNG | - |
dc.contributor.author | Chung, JUNE-KEY | - |
dc.contributor.author | Lee, MYUNG CHUL | - |
dc.contributor.author | Kim, SANG EUN | - |
dc.date.accessioned | 2009-10-05 | - |
dc.date.available | 2009-10-05 | - |
dc.date.issued | 2006-10-14 | - |
dc.identifier.citation | J Surg Oncol 2006;94(7):607-613. | en |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10049 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: Glucose and FDG compete for uptake by cancers. Here, we undertook to improve diagnostic accuracy of FDG-PET for determining mediastinal lymph node (LN) status in NSCLC by considering serum glucose level. METHODS: NSCLC patients (n = 70) who underwent curative lung resection and mediastinal LN dissection within 1 month of FDG-PET were enrolled. MaxSUV was calculated using lean body weight and used to determine a new parameter (maxSUV x serum glucose level; maxSUV-GL). Histopathologic LN results were compared with maxSUV and maxSUV-GL values. RESULTS: Of 71 LN stations whose FDG uptake could be measured, 21 were malignant and 50 benign. MaxSUV of LN had AUC of 0.729 (95% CI: 0.610-0.827) by ROC analysis with sensitivity of 47.6% (10/21), specificity of 94.0% (47/50), and a cutoff value of 3.3. Using maxSUV-GL the corresponding values were; AUC 0.825 (95% CI: 0.716-0.905) and sensitivity 76.2% (16/21), with a cutoff value of 290.4, which represented a significant improvement (P < 0.01) without compromising specificity 88.0% (44/50) (P > 0.05). The exclusion of neo-adjuvant chemotherapeutic and diabetic patients resulted in a similar improvement in diagnostic accuracy. CONCLUSION: By considering serum glucose level during FDG-PET using the new parameter maxSUV-GL, sensitivity for malignant mediastinal LN detection is improved. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Blood Glucose/*analysis | en |
dc.subject | Carcinoma, Non-Small-Cell Lung/blood/*radionuclide imaging/secondary | en |
dc.subject | Diabetes Complications/blood | en |
dc.subject | Fluorodeoxyglucose F18/*diagnostic use/pharmacokinetics | en |
dc.subject | Humans | en |
dc.subject | Lung Neoplasms/blood/pathology/*radionuclide imaging | en |
dc.subject | Lymph Nodes/pathology/*radionuclide imaging | en |
dc.subject | Lymphatic Metastasis | en |
dc.subject | Mediastinum | en |
dc.subject | ROC Curve | en |
dc.subject | Radiopharmaceuticals/*diagnostic use | en |
dc.subject | Sensitivity and Specificity | en |
dc.title | Consideration of serum glucose levels during malignant mediastinal lymph node detection in non-small-cell lung cancer by FDG-PET | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이원우 | - |
dc.contributor.AlternativeAuthor | 정진행 | - |
dc.contributor.AlternativeAuthor | 장성준 | - |
dc.contributor.AlternativeAuthor | 여재선 | - |
dc.contributor.AlternativeAuthor | 박소연 | - |
dc.contributor.AlternativeAuthor | 성숙완 | - |
dc.contributor.AlternativeAuthor | 소영 | - |
dc.contributor.AlternativeAuthor | 정준기 | - |
dc.contributor.AlternativeAuthor | 이명철 | - |
dc.contributor.AlternativeAuthor | 김상은 | - |
dc.identifier.doi | 10.1002/jso.20624 | - |
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