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Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients

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dc.contributor.authorLee, Dae-Won-
dc.contributor.authorHan, Sae-Won-
dc.contributor.authorCha, Yongjun-
dc.contributor.authorLee, Kyung-Hun-
dc.contributor.authorKim, Tae-Yong-
dc.contributor.authorOh, Do-Youn-
dc.contributor.authorIm, Seock-Ah-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorPark, Ji Won-
dc.contributor.authorRyoo, Seung-Bum-
dc.contributor.authorJeong, Seung-Yong-
dc.contributor.authorKang, Gyeong Hoon-
dc.contributor.authorPark, Kyu Joo-
dc.contributor.authorKim, Tae-You-
dc.date.accessioned2017-02-08T01:44:31Z-
dc.date.available2017-02-08T01:44:31Z-
dc.date.issued2015-10-
dc.identifier.citationBMC Cancer, Vol.15, p. 690-
dc.identifier.issn1471-2407-
dc.identifier.other64669-
dc.identifier.urihttps://hdl.handle.net/10371/100525-
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.
ko_KR
dc.description.abstractBackground: Asian population has different body mass index (BMI) profile compared to Caucasian population. However, the effect of obesity and body weight gain in Asian colorectal cancer patients treated with adjuvant chemotherapy has not been studied thus far. Methods: We have analyzed the association between disease-free survival (DFS) and obesity/body weight change during treatment in Korean stage III or high-risk stage II colorectal cancer patients treated with adjuvant 5-fluorouracil/leucovorin/oxaliplatin. BMI was classified according to WHO Asia-Pacific classification. Weight change was calculated by comparing body weights measured at the last chemotherapy cycle and before surgery. Results: Among a total of 522 patients, 35.7 % of patients were obese (BMI >= 25 kg/m(2)) and 29.1 % were overweight (BMI, 23-24.9 kg/m(2)) before surgery. 18.0 % of patients gained = 5 kg and 26.1 % gained 2-4.9 kg during the adjuvant chemotherapy period. Baseline BMI or body weight change was not associated with DFS in the overall study population. However, body weight gain (>= 5 kg) was associated with inferior DFS (adjusted hazard ratio 2.04, 95 % confidence interval 1.02-4.08, p = 0.043) in overweight and obese patients (BMI >= 23.0 kg/m(2)). Conclusion: In Korean colorectal cancer patients treated with adjuvant FOLFOX chemotherapy, body weight gain during the treatment period has a negative prognostic influence in overweight and obese patients.-
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectBody mass index-
dc.subjectObesity-
dc.subjectFOLFOX-
dc.subjectChemotherapy-
dc.subjectColorectal cancer-
dc.titlePrognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1186/s12885-015-1704-0-
dc.citation.journaltitleBMC Cancer-
dc.identifier.scopusid2-s2.0-84944407412-
dc.language.rfc3066en-
dc.rights.holderLee et al.-
dc.date.updated2017-01-06T10:12:34Z-
dc.citation.startpage690-
dc.citation.volume15-
dc.identifier.urlhttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1704-0-
dc.identifier.rimsid64669-
dc.identifier.sci000362705500003-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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