Browse

The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study

Cited 9 time in Web of Science Cited 7 time in Scopus
Authors
Doh, Young Seok; Kim, You Sun; Bae, Song I; Im, Jong Pil; Cheon, Jae Hee; Ye, Byong Duk; Kim, Ji Won; Park, Young Sook; Lee, Ji Hyun; Kim, Young-Ho; Kim, Joo Sung; Han, Dong Soo; Kim, Won Ho
Issue Date
2015-03-18
Publisher
BioMed Central
Citation
BMC Gastroenterology, 15(1):31
Keywords
Crohn’s diseaseIntestinal perforationRisk factorsDelayed diagnosisCohort study
Description
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Abstract
Background
Free perforation is the most severe and debilitating complication associated with Crohn’s disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD.

Methods
The CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study was conducted nationwide in Korea, and patients who were diagnosed with CD between 1982 and 2008 were included in this retrospective study. We investigated the incidence of free perforation among these patients and their clinical characteristics.

Results
A total of 1346 patients were analyzed and 88 patients (6.5%) were identified with free perforation in CD. The mean age of the free perforation group was 31.8 ± 13.0 years, which was significantly higher than that of the non-perforated group (27.5 ± 12.1 years) (p = 0.004). Free perforation was the presenting sign of CD in 46 patients (52%). Of the 94 perforations that were present in 88 patients, 81 involved the ileum. Multivariate logistic regression analysis determined that free perforation was significantly associated with being aged ≥ 30 years at diagnosis (OR 2.082, p = 0.002) and bowel strictures (OR 1.982, p = 0.004). The mortality rate in the free perforation group was significantly higher (4.5%) than that in the non-perforated group (0.6%) (p < 0.001).

Conclusion
The incidence of free perforation in Korean patients with CD was 6.5%. Being aged ≥ 30 years at CD diagnosis and bowel strictures were significant risk factors associated with free perforation.
Language
English
URI
http://hdl.handle.net/10371/100555
DOI
https://doi.org/10.1186/s12876-015-0262-x
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse