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Pretransplant malnutrition, inflammation, and atherosclerosis affect cardiovascular outcomes after kidney transplantation

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dc.contributor.authorHwang, Jin Ho-
dc.contributor.authorRyu, Jiwon-
dc.contributor.authorAn, Jung Nam-
dc.contributor.authorKim, Clara Tammy-
dc.contributor.authorKim, Hyosang-
dc.contributor.authorYang, Jaeseok-
dc.contributor.authorHa, Jongwon-
dc.contributor.authorChae, Dong Wan-
dc.contributor.authorAhn, Curie-
dc.contributor.authorJung, In Mok-
dc.contributor.authorOh, Yun Kyu-
dc.contributor.authorLim, Chun Soo-
dc.contributor.authorHan, Duck-Jong-
dc.contributor.authorPark, Su-Kil-
dc.contributor.authorKim, Yon Su-
dc.contributor.authorKim, Young Hoon-
dc.contributor.authorLee, Jung Pyo-
dc.date.accessioned2017-02-09T00:58:25Z-
dc.date.available2017-02-09T00:58:25Z-
dc.date.issued2015-07-21-
dc.identifier.citationBMC Nephrology, 16(1):109ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100568-
dc.descriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.ko_KR
dc.description.abstractBackground
Malnutrition, inflammation, and atherosclerosis (MIA) syndrome is associated with a high mortality rate in patients with end-stage renal disease. However, the clinical relevance of MIA syndrome in kidney transplantation (KT) recipients remains unknown.

Methods
We enrolled 1348 adult KT recipients. Recipients were assessed based on serum albumin, cholesterol, or body mass index for the malnutrition factor and C-reactive protein level for the inflammation factor. Any history of cardiovascular (CV), cerebrovascular, or peripheral vascular disease satisfied the atherosclerosis factor. Each MIA factors were assessed by univariate analysis and we calculated an overall risk score by summing up scores for each independent variable. The enrolled patients were divided into 4 groups depending on the MIA score (0, 2–4, 6, 8–10).

Results
The patients with higher MIA score showed worse outcome of fatal/non-fatal acute coronary syndrome (ACS) (p < 0.001) and composite outcomes of ACS and all-cause mortality (p < 0.001) than with the lower MIA score. In multivariate analysis, ACS showed significantly higher incidence in the MIA score 8-10 group than in the MIA score 0 group (Hazard ratio 6.12 95 % Confidence interval 1.84–20.32 p = 0.003).

Conclusions
The presence of MIA factors before KT is an independent predictor of post-transplant CV outcomes.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectAcute Coronary Syndromeko_KR
dc.subjectAtherosclerosisko_KR
dc.subjectCardiovascular Outcomeko_KR
dc.subjectInflammationko_KR
dc.subjectKidney Transplantationko_KR
dc.subjectMalnutritionko_KR
dc.titlePretransplant malnutrition, inflammation, and atherosclerosis affect cardiovascular outcomes after kidney transplantationko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor황진호-
dc.contributor.AlternativeAuthor류지원-
dc.contributor.AlternativeAuthor안정남-
dc.contributor.AlternativeAuthor김효상-
dc.contributor.AlternativeAuthor양재석-
dc.contributor.AlternativeAuthor하종원-
dc.contributor.AlternativeAuthor채동완-
dc.contributor.AlternativeAuthor안규리-
dc.contributor.AlternativeAuthor정인목-
dc.contributor.AlternativeAuthor오윤규-
dc.contributor.AlternativeAuthor임천수-
dc.contributor.AlternativeAuthor한덕종-
dc.contributor.AlternativeAuthor박수길-
dc.contributor.AlternativeAuthor김연수-
dc.contributor.AlternativeAuthor김영훈-
dc.contributor.AlternativeAuthor이정표-
dc.identifier.doi10.1186/s12882-015-0108-3-
dc.language.rfc3066en-
dc.rights.holderHwang et al.-
dc.date.updated2017-01-06T10:18:30Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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