KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods

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Kang, Hee Gyung; Choi, Hyun Jin; Han, Kyung Hee; Kim, Seong Heon; Cho, Hee Yeon; Cho, Min Hyun; Shin, Jae Il; Lee, Joo Hoon; Lee, Joongyub; Oh, Kook Hwan; Park, Young Seo; Cheong, Hae Il; Ahn, Curie; Ha, Il-Soo

Issue Date
BioMed Central
BMC Nephrology, 17(1):35
Chronic kidney diseaseCohort studyDesignPrognostic factorAsian children
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The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on childrens growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government.

From seven major centers, 450 patients <20years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50%, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life.

With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients.

Trial registration
NCT02165878(, submitted on June 11, 2014.
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