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KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods

Cited 8 time in Web of Science Cited 7 time in Scopus
Authors
Kang, Hee Gyung; Choi, Hyun Jin; Han, Kyung Hee; Kim, Seong Heon; Cho, Hee Yeon; Cho, Min Hyun; Shin, Jae Il; Lee, Joo Hoon; Lee, Joongyub; Oh, Kook Hwan; Park, Young Seo; Cheong, Hae Il; Ahn, Curie; Ha, Il-Soo
Issue Date
2016-03-25
Publisher
BioMed Central
Citation
BMC Nephrology, 17(1):35
Keywords
Chronic kidney diseaseCohort studyDesignPrognostic factorAsian children
Description
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Abstract
Background
The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children’s growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government.

Methods/design
From seven major centers, 450 patients <20 years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50 %, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life.

Discussion
With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients.

Trial registration
NCT02165878(ClinicalTrials.gov), submitted on June 11, 2014.
Language
English
URI
http://hdl.handle.net/10371/100572
DOI
https://doi.org/10.1186/s12882-016-0248-0
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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