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Granulocyte colony-stimulating factor treatment ameliorates lupus nephritis through the expansion of regulatory T cells
DC Field | Value | Language |
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dc.contributor.author | Yan, Ji-Jing | - |
dc.contributor.author | Jambaldorj, Enkthuya | - |
dc.contributor.author | Lee, Jae-Ghi | - |
dc.contributor.author | Jang, Joon Young | - |
dc.contributor.author | Shim, Jung Min | - |
dc.contributor.author | Han, Miyeun | - |
dc.contributor.author | Koo, Tai Yeon | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.date.accessioned | 2017-02-09T01:25:15Z | - |
dc.date.available | 2017-02-09T01:25:15Z | - |
dc.date.issued | 2016-11-15 | - |
dc.identifier.citation | BMC Nephrology, 17(1):175 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100573 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background Granulocyte colony-stimulating factor (G-CSF) can induce regulatory T cells (Tregs) as well as myeloid-derived suppressor cells (MDSCs). Despite the immune modulatory effects of G-CSF, results of G-CSF treatment in systemic lupus erythematosus are still controversial. We therefore investigated whether G-CSF can ameliorate lupus nephritis and studied the underlying mechanisms. Methods NZB/WF1 female mice were treated with G-CSF or phosphate-buffered saline for 5 consecutive days every week from 24weeks of age, and were analyzed at 36weeks of age. Results G-CSF treatment decreased proteinuria and serum anti-dsDNA, increased serum complement component 3 (C3), and attenuated renal tissue injury including deposition of IgG and C3. G-CSF treatment also decreased serum levels of BUN and creatinine, and ultimately decreased mortality of NZB/WF1 mice. G-CSF treatment induced expansion of CD4+CD25+Foxp3+ Tregs, with decreased renal infiltration of T cells, B cells, inflammatory granulocytes and monocytes in both kidneys and spleen. G-CSF treatment also decreased expression levels of MCP-1, IL-6, IL-2, and IL-10 in renal tissues as well as serum levels of MCP-1, IL-6, TNF-α, IL-10, and IL-17. When Tregs were depleted by PC61 treatment, G-CSF-mediated protective effects on lupus nephritis were abrogated. Conclusions G-CSF treatment ameliorated lupus nephritis through the preferential expansion of CD4+CD25+Foxp3+ Tregs. Therefore, G-CSF has a therapeutic potential for lupus nephritis. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Granulocyte colony-stimulating factor | ko_KR |
dc.subject | Lupus nephritis | ko_KR |
dc.subject | Regulatory T cells | ko_KR |
dc.title | Granulocyte colony-stimulating factor treatment ameliorates lupus nephritis through the expansion of regulatory T cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이재기 | - |
dc.contributor.AlternativeAuthor | 장준영 | - |
dc.contributor.AlternativeAuthor | 심정민 | - |
dc.contributor.AlternativeAuthor | 한미연 | - |
dc.contributor.AlternativeAuthor | 구태연 | - |
dc.contributor.AlternativeAuthor | 안규리 | - |
dc.contributor.AlternativeAuthor | 양재석 | - |
dc.identifier.doi | 10.1186/s12882-016-0380-x | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-01-06T10:18:55Z | - |
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