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Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry

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dc.contributor.authorWon, Ki-Bum-
dc.contributor.authorHur, Seung-Ho-
dc.contributor.authorCho, Yun-Kyeong-
dc.contributor.authorYoon, Hyuck-Jun-
dc.contributor.authorNam, Chang-Wook-
dc.contributor.authorKim, Kwon-Bae-
dc.contributor.authorBae, Jang-Ho-
dc.contributor.authorChoi, Dong-Ju-
dc.contributor.authorAhn, Young-Keun-
dc.contributor.authorPark, Jong-Seon-
dc.contributor.authorKim, Hyo-Soo-
dc.contributor.authorChoi, Rak-Kyeong-
dc.contributor.authorChoi, Donghoon-
dc.contributor.authorKim, Joon-Hong-
dc.contributor.authorHan, Kyoo-Rok-
dc.contributor.authorPark, Hun-Sik-
dc.contributor.authorChoi, So-Yeon-
dc.contributor.authorYoon, Jung-Han-
dc.contributor.authorKwon, Hyeon-Cheol-
dc.contributor.authorRha, Seung-Un-
dc.contributor.authorHwang, Kyung-Kuk-
dc.contributor.authorLim, Do-Sun-
dc.contributor.authorJung, Kyung-Tae-
dc.contributor.authorOh, Seok-Kyu-
dc.contributor.authorLee, Jae-Hwan-
dc.contributor.authorShin, Eun-Seok-
dc.contributor.authorKim, Kee-Sik-
dc.date.accessioned2017-02-10T01:47:55Z-
dc.date.available2017-03-16T16:13:49Z-
dc.date.issued2015-10-15-
dc.identifier.citationCardiovascular Diabetology, 14(1):141ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100668-
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License
(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium,
provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.
ko_KR
dc.description.abstractAbstract

Background
After acute myocardial infarction (AMI), the replicated phenomenon of obesity paradox, i.e., obesity appearing to be associated with increased survival, has not been evaluated in stabilized (i.e., without clinical events within 1 month post AMI) Asian patients with diabetes mellitus (DM).


Methods
Among 1192 patients in the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter registry between April 2010 and June 2012, 2-year cardiac and all-cause death were compared according to obesity (body mass index ≥25 kg/m2) in 1125 stabilized DM patients.


Results
Compared with non-obese DM patients (62 % of AMI patients), obese DM patients had: higher incidence of dyslipidemia (31 vs. 24 %, P < 0.01); lower incidence of chronic kidney disease (26 vs. 33 %) (P < 0.01); higher left ventricular ejection fraction after AMI (53 ± 11 vs. 50 ± 12 %, P < 0.001); and lower 2-year cardiac and all-cause death occurrence (0.7 vs. 3.6 % and 1.9 vs. 5.2 %, both P < 0.01) and cumulative incidence in Kaplan–Meier analysis (P < 0.005, respectively). Likewise, both univariate and multivariate Cox hazard regression analyses adjusted for the respective confounders showed that obesity was associated with decreased risk of both cardiac [HR, 0.18 (95 % CI 0.06–0.60), P = 0.005; and 0.24 (0.07–0.78), P = 0.018, respectively] and all-cause death [0.34 (0.16–0.73), P = 0.005; and 0.44 (0.20–0.95), P = 0.038].


Conclusions
In a Korean population of stabilized DM patients after AMI, non-obese patients appear to have higher cardiac and all-cause mortality compared with obese patients after adjusting for confounding factors.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectType 2 diabetes mellitusko_KR
dc.subjectAcute myocardial infarctionko_KR
dc.subjectObesityko_KR
dc.subjectSurvivalko_KR
dc.titleComparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registryko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor원기범-
dc.contributor.AlternativeAuthor허승호-
dc.contributor.AlternativeAuthor조윤경-
dc.contributor.AlternativeAuthor윤혁준-
dc.contributor.AlternativeAuthor남창욱-
dc.contributor.AlternativeAuthor김권배-
dc.contributor.AlternativeAuthor배장호-
dc.contributor.AlternativeAuthor최동주-
dc.contributor.AlternativeAuthor안영근-
dc.contributor.AlternativeAuthor박종선-
dc.contributor.AlternativeAuthor김효수-
dc.contributor.AlternativeAuthor최락경-
dc.contributor.AlternativeAuthor최동훈-
dc.contributor.AlternativeAuthor김준홍-
dc.contributor.AlternativeAuthor한규록-
dc.contributor.AlternativeAuthor박훈식-
dc.contributor.AlternativeAuthor최소연-
dc.contributor.AlternativeAuthor윤정한-
dc.contributor.AlternativeAuthor권현철-
dc.contributor.AlternativeAuthor라승운-
dc.contributor.AlternativeAuthor황경국-
dc.contributor.AlternativeAuthor임도순-
dc.contributor.AlternativeAuthor정경태-
dc.contributor.AlternativeAuthor오석규-
dc.contributor.AlternativeAuthor이재환-
dc.contributor.AlternativeAuthor신은석-
dc.contributor.AlternativeAuthor김기식-
dc.identifier.doi10.1186/s12933-015-0305-1-
dc.language.rfc3066en-
dc.rights.holderWon et al.-
dc.date.updated2017-01-06T10:24:46Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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