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Impact of metabolic syndrome on the progression of coronary calcium and of coronary artery disease assessed by repeated cardiac computed tomography scans

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dc.contributor.authorKim, Lee Kyung-
dc.contributor.authorYoon, Ji Won-
dc.contributor.authorLee, Dong-Hwa-
dc.contributor.authorKim, Kyoung Min-
dc.contributor.authorChoi, Sung Hee-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorJang, Hak Chul-
dc.contributor.authorKim, Min-Kyung-
dc.contributor.authorPark, Hyo Eun-
dc.contributor.authorChoi, Su-Yeon-
dc.contributor.authorLim, Soo-
dc.date.accessioned2017-02-10T01:56:47Z-
dc.date.available2017-03-16T17:04:49Z-
dc.date.issued2016-06-28-
dc.identifier.citationCardiovascular Diabetology, 15(1):92ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100671-
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License
(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium,
provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.
ko_KR
dc.description.abstractAbstract

Background
It is not clear how severe metabolic syndrome (MS) affects the development of coronary atherosclerosis.


Methods
This was an observational, retrospective cohort study with Koreans who received health check-ups voluntarily. A total of 2426 subjects had baseline and follow-up coronary artery calcium score (CACS) data. Among them, 1079 had coronary computed tomography angiography (CCTA) data. We compared baseline CACS and any progression in subjects with and without MS. A more detailed analysis was conducted for coronary artery disease (CAD), which was defined by coronary artery stenosis (≥50 %), multivessel involvement, and coronary plaques in those patients with CCTA data.


Results
At baseline, subjects with MS (34.0 %, n = 825) had higher CACS and more significant coronary artery stenosis, multivessel involvement, and atheromatous plaques than those without MS (P < 0.05 for all). In the follow-up (median 1197 days), subjects with MS showed significant increases in CACS and progression of CAD compared with counterparts without MS, in parallel with the numbers of MS components. Finally, MS was a significant predictor for the progression of CACS (hazard ratio 1.32; 95 % confidence interval 1.06–1.64) and progression of coronary artery stenosis and/or development of vulnerable plaque (hazard ratio 1.47, 95 % confidence interval 1.01–2.15) after adjusting for other cardiovascular risk factors.


Conclusions
Subjects with MS showed progression of CAD as assessed by CACS and CCTA over ~3 years. Therefore, more vigilant screening for coronary vascular health is needed among those with MS.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectMetabolic syndromeko_KR
dc.subjectCoronary artery calciumko_KR
dc.subjectCoronary artery diseaseko_KR
dc.subjectLongitudinal cohort studyko_KR
dc.titleImpact of metabolic syndrome on the progression of coronary calcium and of coronary artery disease assessed by repeated cardiac computed tomography scansko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김이경-
dc.contributor.AlternativeAuthor윤지원-
dc.contributor.AlternativeAuthor이동화-
dc.contributor.AlternativeAuthor김경민-
dc.contributor.AlternativeAuthor최성희-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor장학철-
dc.contributor.AlternativeAuthor김민경-
dc.contributor.AlternativeAuthor박효은-
dc.contributor.AlternativeAuthor최수연-
dc.contributor.AlternativeAuthor임수-
dc.identifier.doi10.1186/s12933-016-0404-7-
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2017-01-06T10:24:54Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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