Publications
Detailed Information
CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Sei-Myoung | - |
dc.contributor.author | Kim, Hyun-Tae | - |
dc.contributor.author | Kim, Kun-Woo | - |
dc.contributor.author | Jeon, Kee-Ok | - |
dc.contributor.author | Seo, Kyoung-Won | - |
dc.contributor.author | Choi, Eun Wha | - |
dc.contributor.author | Youn, Hwa-Young | - |
dc.date.accessioned | 2017-02-10T02:04:38Z | - |
dc.date.available | 2017-03-16T16:48:27Z | - |
dc.date.issued | 2015-03-06 | - |
dc.identifier.citation | BMC Veterinary Research, 11(1):49 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100675 | - |
dc.description | This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | ko_KR |
dc.description.abstract | Abstract
Background Canine pemphigus foliaceus is an autoimmune antibody-mediated skin disease characterized by acantholysis. The objective of this case report is to present the successful management of steroid refractory pemphigus foliaceus with cytotoxic T-lymphocyte antigen 4 (CTLA4)-overexpressing adipose tissue mesenchymal stem cells (ATMSCs). Case presentation A 10-year-old, 12.3-kg, castrated male Shih Tzu presented with severe pruritus and anorexia. The diagnosis of pemphigus foliaceus was made based on its history, physical examination, and histopathology results of a skin biopsy. Treatment with prednisolone and combination therapy of other immunosuppressive drugs had failed; therefore, immunosuppressive gene, CTLA4 overexpressing ATMSCs (CTLA4-ATMSCs) and/or naive ATMSCs administration was performed with the consent of the owner. ATMSCs were administered 21 times over a period of 20months with intervals of 2 to 8week. Prednisolone was gradually tapered concurrently and no relapse of the clinical signs was observed. After the termination of CTLA4-ATMSCs and/or naive ATMSCs treatment, the skin lesions had improved and could be managed with a low dose of prednisolone for 12months. Conclusion CTLA4-ATMSCs or naive ATMSCs transplantation may be beneficial as adjunctive therapy to initiate and maintain the remission of skin lesions caused by pemphigus foliaceus in veterinary medicine. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Autoimmune disease | ko_KR |
dc.subject | CTLA4 | ko_KR |
dc.subject | Dog | ko_KR |
dc.subject | Mesenchymal stem cell | ko_KR |
dc.subject | Pemphigus foliaceus | ko_KR |
dc.title | CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 한세명 | - |
dc.contributor.AlternativeAuthor | 김현태 | - |
dc.contributor.AlternativeAuthor | 김건우 | - |
dc.contributor.AlternativeAuthor | 전기옥 | - |
dc.contributor.AlternativeAuthor | 서경원 | - |
dc.contributor.AlternativeAuthor | 최은화 | - |
dc.contributor.AlternativeAuthor | 윤화영 | - |
dc.identifier.doi | 10.1186/s12917-015-0371-3 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Han et al.; licensee BioMed Central. | - |
dc.date.updated | 2017-01-06T10:25:35Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.