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CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus

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dc.contributor.authorHan, Sei-Myoung-
dc.contributor.authorKim, Hyun-Tae-
dc.contributor.authorKim, Kun-Woo-
dc.contributor.authorJeon, Kee-Ok-
dc.contributor.authorSeo, Kyoung-Won-
dc.contributor.authorChoi, Eun Wha-
dc.contributor.authorYoun, Hwa-Young-
dc.date.accessioned2017-02-10T02:04:38Z-
dc.date.available2017-03-16T16:48:27Z-
dc.date.issued2015-03-06-
dc.identifier.citationBMC Veterinary Research, 11(1):49ko_KR
dc.identifier.urihttp://hdl.handle.net/10371/100675-
dc.descriptionThis is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly credited.
ko_KR
dc.description.abstractAbstract

Background
Canine pemphigus foliaceus is an autoimmune antibody-mediated skin disease characterized by acantholysis. The objective of this case report is to present the successful management of steroid refractory pemphigus foliaceus with cytotoxic T-lymphocyte antigen 4 (CTLA4)-overexpressing adipose tissue mesenchymal stem cells (ATMSCs).


Case presentation
A 10-year-old, 12.3-kg, castrated male Shih Tzu presented with severe pruritus and anorexia. The diagnosis of pemphigus foliaceus was made based on its history, physical examination, and histopathology results of a skin biopsy. Treatment with prednisolone and combination therapy of other immunosuppressive drugs had failed; therefore, immunosuppressive gene, CTLA4 overexpressing ATMSCs (CTLA4-ATMSCs) and/or naive ATMSCs administration was performed with the consent of the owner. ATMSCs were administered 21 times over a period of 20 months with intervals of 2 to 8 week. Prednisolone was gradually tapered concurrently and no relapse of the clinical signs was observed. After the termination of CTLA4-ATMSCs and/or naive ATMSCs treatment, the skin lesions had improved and could be managed with a low dose of prednisolone for 12 months.


Conclusion
CTLA4-ATMSCs or naive ATMSCs transplantation may be beneficial as adjunctive therapy to initiate and maintain the remission of skin lesions caused by pemphigus foliaceus in veterinary medicine.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectAutoimmune diseaseko_KR
dc.subjectCTLA4ko_KR
dc.subjectDogko_KR
dc.subjectMesenchymal stem cellko_KR
dc.subjectPemphigus foliaceusko_KR
dc.titleCTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceusko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor한세명-
dc.contributor.AlternativeAuthor김현태-
dc.contributor.AlternativeAuthor김건우-
dc.contributor.AlternativeAuthor전기옥-
dc.contributor.AlternativeAuthor서경원-
dc.contributor.AlternativeAuthor최은화-
dc.contributor.AlternativeAuthor윤화영-
dc.identifier.doi10.1186/s12917-015-0371-3-
dc.language.rfc3066en-
dc.rights.holderHan et al.; licensee BioMed Central.-
dc.date.updated2017-01-06T10:25:35Z-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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