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Combined analysis of gene regulatory network and SNV information enhances identification of potential gene markers in mouse knockout studies with small number of samples
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hur, Benjamin | - |
dc.contributor.author | Chae, Heejoon | - |
dc.contributor.author | Kim, Sun | - |
dc.date.accessioned | 2017-02-10T02:10:13Z | - |
dc.date.available | 2017-03-16T16:04:00Z | - |
dc.date.issued | 2015-05-29 | - |
dc.identifier.citation | BMC Medical Genomics, 8(Suppl 2):S10 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100679 | - |
dc.description | This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ko_KR |
dc.description.abstract | Abstract
RNA-sequencing is widely used to measure gene expression level at the whole genome level. Comparing expression data from control and case studies provides good insight on potential gene markers for phenotypes. However, discovering gene markers that represent phenotypic differences in a small number of samples remains a challenging task, since finding gene markers using standard differential expressed gene methods produces too many candidate genes and the number of candidates varies at different threshold values. In addition, in a small number of samples, the statistical power is too low to discriminate whether gene expressions were altered by genetic differences or not. In this study, to address this challenge, we purpose a four-step filtering method that predicts gene markers from RNA-sequencing data of mouse knockout studies by utilizing a gene regulatory network constructed from omics data in the public domain, biological knowledge from curated pathways, and information of single-nucleotide variants. Our prediction method was not only able to reduce the number of candidate genes than the differentialy expressed gene-only filtered method, but also successfully predicted significant genes that were reported in research findings of the data contributors. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | Combined analysis of gene regulatory network and SNV information enhances identification of potential gene markers in mouse knockout studies with small number of samples | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 허벤자민 | - |
dc.contributor.AlternativeAuthor | 채희준 | - |
dc.contributor.AlternativeAuthor | 김선 | - |
dc.identifier.doi | 10.1186/1755-8794-8-S2-S10 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Hur et al.; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-06T10:26:27Z | - |
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