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Genome sequence of type strain of Staphylococcus aureus subsp. aureus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Bong-Soo | - |
dc.contributor.author | Yi, Hana | - |
dc.contributor.author | Chun, Jongsik | - |
dc.contributor.author | Cha, Chang-Jun | - |
dc.date.accessioned | 2017-02-10T02:27:42Z | - |
dc.date.available | 2017-03-16T16:59:14Z | - |
dc.date.issued | 2014-03-17 | - |
dc.identifier.citation | Gut Pathogens, 6(1):6 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100686 | - |
dc.description | This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | ko_KR |
dc.description.abstract | Abstract
Background Staphylococcus aureus is a pathogen that causes food poisoning and community-associated infection with antibiotic resistance. This species is an indigenous intestinal microbe found in infants and not found in adult intestine. The relatively small genome size and rapid evolution of antibiotic resistance genes in the species have been drawing an increasing attention in public health. To extend our understanding of the species and use the genome data for comparative genomic studies, we sequenced the type strain of S. aureus subsp. aureus DSM 20231T. Results Seventeen contigs were generated using hybrid assembly of sequences derived from the Roche 454 and Illumina systems. The length of the genome sequence was 2,902,619 bases with a G + C content of 32.8%. Among the 2,550 annotated CDSs, 44 CDSs were annotated to antibiotic resistance genes and 13 CDSs were related to methicillin resistance. It is interesting to note that this strain was first isolated in 1884 before methicillin was generally used on patients. Conclusions The present study analyzed the genome sequence of S. aureus subsp. aureus type strain as the reference sequence for comparative genomic analyses of clinical isolates. Methicillin resistance genes found in the genome indicate the presence of antibiotic resistance mechanism prior to the usage of antibiotics. Further comparative genomic studies of methicillin-resistant strains based on this reference genome would help to understand the evolution of resistance mechanism and dissemination of resistance genes. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Staphylococcus aureus subsp. aureus | ko_KR |
dc.subject | Genome sequencing | ko_KR |
dc.subject | Type strain | ko_KR |
dc.subject | Hybrid assembly | ko_KR |
dc.title | Genome sequence of type strain of Staphylococcus aureus subsp. aureus | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김봉수 | - |
dc.contributor.AlternativeAuthor | 이하나 | - |
dc.contributor.AlternativeAuthor | 전종식 | - |
dc.contributor.AlternativeAuthor | 차창준 | - |
dc.identifier.doi | 10.1186/1757-4749-6-6 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Kim et al.; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-06T10:27:23Z | - |
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