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Radiofrequency thermal ablation in canine femur: evaluation of coagulation necrosis reproducibility and MRI-histopathologic correlation

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dc.contributor.authorLee, Jeong Min-
dc.contributor.authorChoi, Seong Hong-
dc.contributor.authorPark, Hee Seon-
dc.contributor.authorLee, Min Woo-
dc.contributor.authorHan, Chang Jin-
dc.contributor.authorChoi, Joon-il-
dc.contributor.authorChoi, Ja-Young-
dc.contributor.authorHong, Sung Hwan-
dc.contributor.authorHan, Joon Koo-
dc.contributor.authorChoi, Byung Ihn-
dc.date.accessioned2009-10-05T03:56:56Z-
dc.date.available2009-10-05T03:56:56Z-
dc.date.issued2005-08-27-
dc.identifier.citationAJR 2005; 185:661–667en
dc.identifier.issn0361-803X (Print)-
dc.identifier.issn1546-3141 (Electronic)-
dc.identifier.urihttps://hdl.handle.net/10371/10069-
dc.description.abstractOBJECTIVE: Our purposes were to determine whether a single application of radiofrequency energy to normal bone can create coagulation necrosis reproducibly and to assess the accuracy of MRI at revealing the extent of radiofrequency-induced thermal bone injury. MATERIALS AND METHODS: Using a 200-W generator and a 17-gauge cooled-tip electrode, a total of 11 radiofrequency ablations were performed under fluoroscopic guidance in the distal femurs of seven dogs. Radiofrequency was applied in standard monopolar mode at 100 W for 10 min. During radiofrequency ablation, the changes in impedance and currents were recorded. MRI, including unenhanced T1- and T2-weighted images and contrast-enhanced fat-suppressed T1-weighted images, was performed to evaluate ablation regions. Six dogs were killed on day 4 after MRI and one dog on day 7. RESULTS: In all animals, radiofrequency ablation created a well-defined coagulation necrosis and no significant complications were noted. The mean long-axis diameter and the mean short-axis diameter of the coagulation zones produced were 45.9 +/- 5.5 mm and 17.7 +/- 2.7 mm, respectively. At gross examination, thermal ablation regions appeared as a central, light-brown area with a dark-brown peripheral hemorrhagic zone, which was surrounded by a pale-yellow rim. On MRI, the ablated areas showed multilayered zones with signal intensities that differed from normal marrow on unenhanced images and a perfusion defect on contrast-enhanced T1-weighted images. The maximum difference between lesion sizes on MR images, established by measuring macroscopic coagulation necrosis, was 3 mm. The correlation between the diameter of coagulation necrosis and lesion size at MRI was strong, with correlation coefficients ranging from 0.89 for unenhanced T1-weighted images and 0.97 for unenhanced T2-weighted images to 0.98 for contrast-enhanced T1-weighted images (p < 0.05). CONCLUSION: Radiofrequency ablation created well-defined coagulation necrosis in a reproducible manner, and MRI accurately determined the extent of the radiofrequency-induced thermal bone injury.en
dc.language.isoenen
dc.publisherAmerican Roentgen Ray Societyen
dc.titleRadiofrequency thermal ablation in canine femur: evaluation of coagulation necrosis reproducibility and MRI-histopathologic correlationen
dc.typeArticleen
dc.contributor.AlternativeAuthor이정민-
dc.contributor.AlternativeAuthor최성홍-
dc.contributor.AlternativeAuthor박희선-
dc.contributor.AlternativeAuthor이민우-
dc.contributor.AlternativeAuthor한창진-
dc.contributor.AlternativeAuthor최준일-
dc.contributor.AlternativeAuthor최자영-
dc.contributor.AlternativeAuthor홍성환-
dc.contributor.AlternativeAuthor한준구-
dc.contributor.AlternativeAuthor최병인-
dc.identifier.doi10.1007/s00247-005-1439-1-
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