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Radiofrequency thermal ablation in canine femur: evaluation of coagulation necrosis reproducibility and MRI-histopathologic correlation
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong Min | - |
dc.contributor.author | Choi, Seong Hong | - |
dc.contributor.author | Park, Hee Seon | - |
dc.contributor.author | Lee, Min Woo | - |
dc.contributor.author | Han, Chang Jin | - |
dc.contributor.author | Choi, Joon-il | - |
dc.contributor.author | Choi, Ja-Young | - |
dc.contributor.author | Hong, Sung Hwan | - |
dc.contributor.author | Han, Joon Koo | - |
dc.contributor.author | Choi, Byung Ihn | - |
dc.date.accessioned | 2009-10-05T03:56:56Z | - |
dc.date.available | 2009-10-05T03:56:56Z | - |
dc.date.issued | 2005-08-27 | - |
dc.identifier.citation | AJR 2005; 185:661–667 | en |
dc.identifier.issn | 0361-803X (Print) | - |
dc.identifier.issn | 1546-3141 (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/10069 | - |
dc.description.abstract | OBJECTIVE: Our purposes were to determine whether a single application of radiofrequency energy to normal bone can create coagulation necrosis reproducibly and to assess the accuracy of MRI at revealing the extent of radiofrequency-induced thermal bone injury. MATERIALS AND METHODS: Using a 200-W generator and a 17-gauge cooled-tip electrode, a total of 11 radiofrequency ablations were performed under fluoroscopic guidance in the distal femurs of seven dogs. Radiofrequency was applied in standard monopolar mode at 100 W for 10 min. During radiofrequency ablation, the changes in impedance and currents were recorded. MRI, including unenhanced T1- and T2-weighted images and contrast-enhanced fat-suppressed T1-weighted images, was performed to evaluate ablation regions. Six dogs were killed on day 4 after MRI and one dog on day 7. RESULTS: In all animals, radiofrequency ablation created a well-defined coagulation necrosis and no significant complications were noted. The mean long-axis diameter and the mean short-axis diameter of the coagulation zones produced were 45.9 +/- 5.5 mm and 17.7 +/- 2.7 mm, respectively. At gross examination, thermal ablation regions appeared as a central, light-brown area with a dark-brown peripheral hemorrhagic zone, which was surrounded by a pale-yellow rim. On MRI, the ablated areas showed multilayered zones with signal intensities that differed from normal marrow on unenhanced images and a perfusion defect on contrast-enhanced T1-weighted images. The maximum difference between lesion sizes on MR images, established by measuring macroscopic coagulation necrosis, was 3 mm. The correlation between the diameter of coagulation necrosis and lesion size at MRI was strong, with correlation coefficients ranging from 0.89 for unenhanced T1-weighted images and 0.97 for unenhanced T2-weighted images to 0.98 for contrast-enhanced T1-weighted images (p < 0.05). CONCLUSION: Radiofrequency ablation created well-defined coagulation necrosis in a reproducible manner, and MRI accurately determined the extent of the radiofrequency-induced thermal bone injury. | en |
dc.language.iso | en | en |
dc.publisher | American Roentgen Ray Society | en |
dc.title | Radiofrequency thermal ablation in canine femur: evaluation of coagulation necrosis reproducibility and MRI-histopathologic correlation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이정민 | - |
dc.contributor.AlternativeAuthor | 최성홍 | - |
dc.contributor.AlternativeAuthor | 박희선 | - |
dc.contributor.AlternativeAuthor | 이민우 | - |
dc.contributor.AlternativeAuthor | 한창진 | - |
dc.contributor.AlternativeAuthor | 최준일 | - |
dc.contributor.AlternativeAuthor | 최자영 | - |
dc.contributor.AlternativeAuthor | 홍성환 | - |
dc.contributor.AlternativeAuthor | 한준구 | - |
dc.contributor.AlternativeAuthor | 최병인 | - |
dc.identifier.doi | 10.1007/s00247-005-1439-1 | - |
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