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Isolated full-thickness cervical stromal invasion warrants post-hysterectomy pelvic radiotherapy in FIGO stages IB-IIA uterine cervical carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Sung Ho | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Ha, Sung W | - |
dc.contributor.author | Lee, Hyo Pyo | - |
dc.contributor.author | Kang, Soon Beom | - |
dc.contributor.author | Song, Yong Sang | - |
dc.contributor.author | Park, Noh Hyun | - |
dc.contributor.author | Kim, Jae Won | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Kim, Baek Hui | - |
dc.date.accessioned | 2009-10-13T23:45:23Z | - |
dc.date.available | 2009-10-13T23:45:23Z | - |
dc.date.issued | 2006-08-28 | - |
dc.identifier.citation | Gynecol Oncol 2006;104:152-7 | en |
dc.identifier.issn | 0090-8258 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG6-4KRY3J9-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=02e38851e0a1120e1db0a4c3c09bf681 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16935323 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10422 | - |
dc.description.abstract | OBJECTIVE: To evaluate the potential benefit of postoperative radiotherapy (PORT) in women with isolated full-thickness cervical stromal invasion (FTSI) as an unfavorable pathological finding after radical hysterectomy and pelvic lymph node dissection (PLND) in FIGO stages IB-IIA cervical carcinoma. METHODS: A total of 1868 patients with stages IB-IIA cervical carcinoma underwent radical hysterectomy and PLND between January 1982 and December 2002. Seventy-four of these patients had isolated FTSI without any other unfavorable pathological finding, such as lymph node metastasis, microscopic parametrial involvement, involved resection margin, lympho-vascular space invasion, or large clinical tumor diameter (>4 cm). Forty-one of these patients had no adjuvant treatment (S group) and 33 received PORT (PORT group). Patients with isolated FTSI who received chemotherapy were excluded. Treatment outcomes in the PORT and S groups were compared. RESULTS: Ten-year disease-free survival (DFS) and pelvic-failure-free survival (PFFS) of S group vs. PORT group were 73.2% vs. 92.4% (P=0.038) and 79.8% vs. 97.0% (P=0.044), respectively. According to a Cox proportional hazards model developed by forward, stepwise regression incorporating all prognostic variables, only PORT was marginally significant for DFS (RR 0.234; 95% CI 0.051-1.067; P=0.061) and significant for PFFS (RR 0.055; 95% CI 0.005-0.620; P=0.019). A grade 4 late complication developed in two patients (6%) in PORT group. CONCLUSION: PORT administered to patients with isolated FTSI after radical hysterectomy and PLND improves pelvic control in FIGO stages IB-IIA cervical carcinoma with acceptable morbidity. | en |
dc.language.iso | en | en |
dc.publisher | Academic Press | en |
dc.publisher | Elsevier | en |
dc.subject | Combined Modality Therapy | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Hysterectomy | en |
dc.subject | Lymph Node Excision | en |
dc.subject | Lymphatic Metastasis | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Invasiveness | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Prognosis | en |
dc.subject | Radiotherapy/adverse effects | en |
dc.subject | Stromal Cells/pathology | en |
dc.subject | Survival Rate | en |
dc.subject | Treatment Outcome | en |
dc.subject | Uterine Cervical Neoplasms/*pathology/*radiotherapy/surgery | en |
dc.title | Isolated full-thickness cervical stromal invasion warrants post-hysterectomy pelvic radiotherapy in FIGO stages IB-IIA uterine cervical carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문성호 | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.contributor.AlternativeAuthor | 이호표 | - |
dc.contributor.AlternativeAuthor | 강순범 | - |
dc.contributor.AlternativeAuthor | 송영상 | - |
dc.contributor.AlternativeAuthor | 박노현 | - |
dc.contributor.AlternativeAuthor | 김재원 | - |
dc.contributor.AlternativeAuthor | 박인애 | - |
dc.contributor.AlternativeAuthor | 김백희 | - |
dc.identifier.doi | 10.1016/j.ygyno.2006.07.012 | - |
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