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Adjuvant chemotherapy in the management of pT3N0M0 transitional cell carcinoma of the upper urinary tract

Cited 38 time in Web of Science Cited 46 time in Scopus
Authors
Lee, Sang Eun; Byun, Seok-Soo; Park, Yong Hyun; Chang, In Ho; Kim, Yong June; Hong, Sung Kyu
Issue Date
2006
Publisher
Karger
Citation
Urol Int 2006;77(1):22-26
Keywords
Transitional cell carcinomaupper urinary tractRadical nephroureterectomyregional lymphadenectomyAdjuvant chemotherapyupper urinary tract transitional cell carcinoma
Abstract
INTRODUCTION: We investigate the efficacy of postoperative adjuvant chemotherapy for locally advanced, but lymph node negative, pathologic stage T3 transitional cell carcinoma (TCC) of the upper urinary tract. PATIENTS AND METHODS: A retrospective study on 27 patients who had undergone radical nephroureterectomy with regional lymphadenectomy for pT3N0M0 primary upper urinary tract TCC at our institution from 1996 to 2001 was performed. Among the 27 patients, 16 also received adjuvant chemotherapy following surgery (adjuvant group), whereas the other 11 patients did not (nonadjuvant group). RESULTS: Adjuvant and nonadjuvant therapy groups were not significantly different with respect to age, sex, performance status, tumor grade, and tumor location. Overall, 5 of the 16 patients (31%) in the adjuvant group and 4 of the 11 patients (36%) in the nonadjuvant group had recurrence of cancer at 40 months of follow-up. The two groups demonstrated no significant differences in recurrence-free survival (p = 0.794) and disease-specific survival (p = 0.783). CONCLUSIONS: Although it would be difficult to draw any definite conclusions from the results of our investigations, our data suggest that adjuvant therapy with traditional conventional chemotherapeutic regimens alone may not be effective as previously anticipated in significantly improving survival rates for locally advanced, but lymph node negative, TCC of the upper urinary tract.
ISSN
0042-1138 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16825811

https://hdl.handle.net/10371/10590
DOI
https://doi.org/10.1159/000092930
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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