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Biodistribution and excretion of radioactivity after the administration of 166Ho-chitosan complex (DW-166HC) into the prostate of rat
DC Field | Value | Language |
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dc.contributor.author | Seong, Seung Kyoo | - |
dc.contributor.author | Ryu, Jei Man | - |
dc.contributor.author | Shin, Dong Hyuk | - |
dc.contributor.author | Bae, Eun Jeong | - |
dc.contributor.author | Shigematsu, Akiyo | - |
dc.contributor.author | Hatori, Yasuhiko | - |
dc.contributor.author | Nishigaki, Junko | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.contributor.author | Park, Kyong Bae | - |
dc.date.accessioned | 2009-10-26 | - |
dc.date.available | 2009-10-26 | - |
dc.date.issued | 2005-04-20 | - |
dc.identifier.citation | Eur J Nucl Med Mol Imaging 2005;32:910-7 | en |
dc.identifier.issn | 1619-7070 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15841375 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10673 | - |
dc.description.abstract | PURPOSE: The objective of this study was to determine the fate of the 166Ho-chitosan complex (DW-166HC) in rats by examining its absorption, distribution and excretion after administration into the prostate. METHODS: About 100 microCi of DW-166HC [containing 0.1875 mg of Ho(NO3)3.5H2O and 0.25 mg of chitosan] was administered intraprostatically. The level of radioactivity in blood, urinary and faecal excretion, and radioactivity distribution were examined. To determine the effect of chitosan in DW-166HC, 166Ho nitrate alone [0.1875 mg of Ho(NO3)3.5H2O] was administered into the prostate of male rats, and radioactivity distribution was examined using whole-body autoradiography. RESULTS: After administration of DW-166HC into the prostate, cumulative urinary and faecal excretion over the period 0-72 h was 0.35% and 0.11%, respectively. The radioactivity at the administration site was extremely high at all time points up to 144 h (>98% of injected dose). The small amount of radioactivity which did transfer from the administration site distributed mainly to the liver, spleen, kidney cortex and bone. Compared with the DW-166HC group, the group that received 166Ho nitrate alone displayed three- to fourfold higher levels of radioactivity in the main tissues, including liver, spleen, kidney cortex and bone, at 24 h after administration (P < 0.05). CONCLUSION: The results of this study show clearly that most of the administered DW-166HC remained at the administration site. It is concluded that the chitosan complex may be used to retain 166Ho within a limited area in cancer of the prostate. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Prostate cancer | en |
dc.subject | DW-166HC | en |
dc.subject | Intraprostatically | en |
dc.title | Biodistribution and excretion of radioactivity after the administration of 166Ho-chitosan complex (DW-166HC) into the prostate of rat | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 성승규 | - |
dc.contributor.AlternativeAuthor | 류제만 | - |
dc.contributor.AlternativeAuthor | 신동혁 | - |
dc.contributor.AlternativeAuthor | 배은정 | - |
dc.contributor.AlternativeAuthor | 곽철 | - |
dc.contributor.AlternativeAuthor | 이상은 | - |
dc.contributor.AlternativeAuthor | 박경배 | - |
dc.identifier.doi | 10.1007/s00259-005-1792-1 | - |
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