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Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis

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dc.contributor.authorFukuyama, Satoshi-
dc.contributor.authorNagatake, Takahiro-
dc.contributor.authorKim, Dong-Young-
dc.contributor.authorTakamura, Kaoru-
dc.contributor.authorPark, Eun Jeong-
dc.contributor.authorKaisho, Tsuneyasu-
dc.contributor.authorTanaka, Norimitsu-
dc.contributor.authorKurono, Yuichi-
dc.contributor.authorKiyono, Hiroshi-
dc.date.accessioned2009-10-27T10:15:47Z-
dc.date.available2009-10-27T10:15:47Z-
dc.date.issued2006-
dc.identifier.citationJ. Immunol. 177:4276-4280en
dc.identifier.issn0022-1767 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16982861-
dc.identifier.urihttps://hdl.handle.net/10371/10821-
dc.description.abstractCD3(-)CD4(+)CD45(+) inducer cells are required for the initiation of mucosa-associated organogenesis of both nasopharynx-associated lymphoid tissues (NALT) and Peyer's patches (PP) in the aerodigestive tract. CXCL13(-/-) mice and mice carrying the paucity of lymph node T cell (plt) mutation and lacking expression of CCL19 and CCL21 accumulate CD3(-)CD4(+)CD45(+) cells at the site of NALT but not of PP genesis. Although NALT was observed to develop in adult CXCL13(-/-) and plt/plt mice, the formation of germinal centers in CXCL13(-/-) mice was affected, and their population of B cells was much lower than in the NALT of CXCL13(+/-) mice. Similarly, fewer T cells were observed in the NALT of plt/plt mice than in control mice. These findings indicate that the initiation of NALT organogenesis is independent of CXCL13, CCL19, and CCL21. However, the expression of these lymphoid chemokines is essential for the maturation of NALT microarchitecture.en
dc.description.sponsorshipThis work was supported by the Core Research for Evolutional Science and Technology
Program, from Japan Science and Technology Corporation, and a Grant-in-Aid from the
Ministry of Education, Science, Sports, and Culture and the Ministry of Health and Welfare
of Japan. S.F. was supported by research fellowships from the Japan Society for the
Promotion of Science for Young Scientists. D.-Y.K. was supported by research fellowships
from the Japan Society for the Promotion of Science for Foreign Researchers.
en
dc.language.isoenen
dc.publisherAmerican Association of Immunologistsen
dc.subjectAnimalsen
dc.subjectAntigens, CD3/immunology/metabolismen
dc.subjectAntigens, CD4/immunology/metabolismen
dc.subjectAntigens, CD45/immunology/metabolismen
dc.subjectB-Lymphocytes/immunologyen
dc.subjectChemokine CCL19en
dc.subjectChemokine CCL21en
dc.subjectChemokine CXCL13en
dc.subjectChemokines/*immunology/metabolismen
dc.subjectChemokines, CC/deficiency/geneticsen
dc.subjectChemokines, CXC/deficiency/geneticsen
dc.subjectEmbryo, Mammalianen
dc.subjectFlow Cytometryen
dc.subjectGerminal Center/immunologyen
dc.subjectImmunohistochemistryen
dc.subjectLymphoid Tissue/cytology/*embryology/immunologyen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Mutant Strainsen
dc.subjectNasopharynx/cytology/*immunologyen
dc.subjectOrganogenesis/*immunologyen
dc.subjectPeyer's Patches/cytology/embryology/immunologyen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.subjectT-Lymphocytes/immunologyen
dc.titleCutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesisen
dc.typeArticleen
dc.contributor.AlternativeAuthor김동영-
dc.contributor.AlternativeAuthor박은정-
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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