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A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode
DC Field | Value | Language |
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dc.contributor.author | Ahn, Mi-Hyun | - |
dc.contributor.author | Park, Byung-Lae | - |
dc.contributor.author | Lee, Shin-Hwa | - |
dc.contributor.author | Park, Sung-Woo | - |
dc.contributor.author | Park, Jong-Sook | - |
dc.contributor.author | Kim, Do-Jin | - |
dc.contributor.author | Jang, An-Soo | - |
dc.contributor.author | Park, Jai-Soung | - |
dc.contributor.author | Shin, Hwa-Kyun | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Kim, Yang-Ki | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Jung, Ki-Suck | - |
dc.contributor.author | Lee, Kye Young | - |
dc.contributor.author | Jeong, Sung Hwan | - |
dc.contributor.author | Park, Jeong Woong | - |
dc.contributor.author | Choi, Byoung Whui | - |
dc.contributor.author | Park, In Won | - |
dc.contributor.author | Chung, Man Pyo | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Song, Jin Woo | - |
dc.contributor.author | Kim, Dong Soon | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Shim, Young-Soo | - |
dc.date.accessioned | 2017-03-17T05:47:16Z | - |
dc.date.available | 2017-03-17T14:54:45Z | - |
dc.date.issued | 2011-12-01 | - |
dc.identifier.citation | Respiratory Research, 12(1):73 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109789 | - |
dc.description.abstract | Background
Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased in the lung with IPF. We evaluated the effect of single nucleotide polymorphisms (SNPs) of the IL-8 gene on the risk of IPF. Methods One promoter (rs4073T>A) and two intronic SNPs (rs2227307T>G and rs2227306C>T) of the IL-8 genes were genotyped in 237 subjects with IPF and 456 normal controls. Logistic regression analysis was applied to evaluate the association of these SNPs with IPF. IL-8 in BAL fluids was measured using a quantitative sandwich enzyme immunoassay, and promoter activity was assessed using the luciferase reporter assay. Results The minor allele frequencies of rs4073T>A and rs2227307T>G were significantly lower in the 162 subjects with surgical biopsy-proven IPF and 75 subjects with clinical IPF compared with normal controls in the recessive model (OR = 0.46 and 0.48, p = 0.006 and 0.007, respectively). The IL-8 protein concentration in BAL fluids significantly increased in 24 subjects with IPF compared with 14 controls (p = 0.009). Nine IPF subjects homozygous for the rs4073 T>A common allele exhibited higher levels of the IL-8 protein compared with six subjects homozygous for the minor allele (p = 0.024). The luciferase activity of the rs4073T>A common allele was significantly higher than that of the rs4073T>A minor allele (p = 0.002). Conclusion The common allele of a promoter SNP, rs4073T>A, may increase susceptibility to the development of IPF via up-regulation of IL-8. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 안미현 | - |
dc.contributor.AlternativeAuthor | 박병래 | - |
dc.contributor.AlternativeAuthor | 이신화 | - |
dc.contributor.AlternativeAuthor | 박성우 | - |
dc.contributor.AlternativeAuthor | 박종숙 | - |
dc.contributor.AlternativeAuthor | 김도진 | - |
dc.contributor.AlternativeAuthor | 장안수 | - |
dc.contributor.AlternativeAuthor | 박재성 | - |
dc.contributor.AlternativeAuthor | 신화균 | - |
dc.contributor.AlternativeAuthor | 어수택 | - |
dc.contributor.AlternativeAuthor | 김양기 | - |
dc.contributor.AlternativeAuthor | 김영환 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 정기석 | - |
dc.contributor.AlternativeAuthor | 이계영 | - |
dc.contributor.AlternativeAuthor | 정성환 | - |
dc.contributor.AlternativeAuthor | 박정웅 | - |
dc.contributor.AlternativeAuthor | 최병휘 | - |
dc.contributor.AlternativeAuthor | 박인원 | - |
dc.contributor.AlternativeAuthor | 정만표 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 송진우 | - |
dc.contributor.AlternativeAuthor | 김동순 | - |
dc.contributor.AlternativeAuthor | 박춘식 | - |
dc.contributor.AlternativeAuthor | 심영수 | - |
dc.identifier.doi | 10.1186/1465-9921-12-73 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Park and Kim et al; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-06T10:31:31Z | - |
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