Publications
Detailed Information
Subchronic oral toxicity of silver nanoparticles
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yong Soon | - |
dc.contributor.author | Song, Moon Yong | - |
dc.contributor.author | Park, Jung Duck | - |
dc.contributor.author | Song, Kyung Seuk | - |
dc.contributor.author | Ryu, Hyeon Ryol | - |
dc.contributor.author | Chung, Yong Hyun | - |
dc.contributor.author | Chang, Hee Kyung | - |
dc.contributor.author | Lee, Ji Hyun | - |
dc.contributor.author | Oh, Kyung Hui | - |
dc.contributor.author | Kelman, Bruce J | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Yu, Il Je | - |
dc.date.accessioned | 2017-03-17T06:18:15Z | - |
dc.date.available | 2017-03-17T16:25:01Z | - |
dc.date.issued | 2010-08-06 | - |
dc.identifier.citation | Particle and Fibre Toxicology, 7(1):20 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109795 | - |
dc.description.abstract | Background
The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, consumer, medicinal, pesticide, and home products; however, silver nanoparticles remain a controversial area of research with respect to their toxicity in biological and ecological systems. Results This study tested the oral toxicity of silver nanoparticles (56 nm) over a period of 13 weeks (90 days) in F344 rats following Organization for Economic Cooperation and Development (OECD) test guideline 408 and Good Laboratory Practices (GLP). Five-week-old rats, weighing about 99 g for the males and 92 g for the females, were divided into four 4 groups (10 rats in each group): vehicle control, low-dose (30 mg/kg), middle-dose (125 mg/kg), and high-dose (500 mg/kg). After 90 days of exposure, clinical chemistry, hematology, histopathology, and silver distribution were studied. There was a significant decrease (P < 0.05) in the body weight of male rats after 4 weeks of exposure, although there were no significant changes in food or water consumption during the study period. Significant dose-dependent changes were found in alkaline phosphatase and cholesterol for the male and female rats, indicating that exposure to more than 125 mg/kg of silver nanoparticles may result in slight liver damage. Histopathologic examination revealed a higher incidence of bile-duct hyperplasia, with or without necrosis, fibrosis, and/or pigmentation, in treated animals. There was also a dose-dependent accumulation of silver in all tissues examined. A gender-related difference in the accumulation of silver was noted in the kidneys, with a twofold increase in female kidneys compared to male kidneys. Conclusions The target organ for the silver nanoparticles was found to be the liver in both the male and female rats. A NOAEL (no observable adverse effect level) of 30 mg/kg and LOAEL (lowest observable adverse effect level) of 125 mg/kg are suggested from the present study. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | Subchronic oral toxicity of silver nanoparticles | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김용순 | - |
dc.contributor.AlternativeAuthor | 송문용 | - |
dc.contributor.AlternativeAuthor | 박정덕 | - |
dc.contributor.AlternativeAuthor | 송경석 | - |
dc.contributor.AlternativeAuthor | 류현렬 | - |
dc.contributor.AlternativeAuthor | 정용현 | - |
dc.contributor.AlternativeAuthor | 장희경 | - |
dc.contributor.AlternativeAuthor | 이지현 | - |
dc.contributor.AlternativeAuthor | 오경희 | - |
dc.contributor.AlternativeAuthor | 황인구 | - |
dc.contributor.AlternativeAuthor | 유일제 | - |
dc.identifier.doi | 10.1186/1743-8977-7-20 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Kim et al; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-06T10:32:23Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.