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Effect of HX108-CS supplementation on exercise capacity and lactate accumulation after high-intensity exercise

Cited 5 time in Web of Science Cited 5 time in Scopus
Authors
Oh, Seung-Lyul; Chang, Hyukki; Kim, Hee-Jae; Kim, Yong-An; Kim, Dong-Sik; Ho, Seong-Hyun; Kim, Seon-Hee; Song, Wook
Issue Date
2013-04-15
Publisher
BioMed Central
Citation
Journal of the International Society of Sports Nutrition, 10(1):21
Keywords
HX108-CSSchisandra chinensisChaenomeles sinensisEndurance capacityExercise capacityLactate accumulation
Abstract
Background
In the present study, we determined the effects of HX108-CS (mixed extract of Schisandra chinensis and Chaenomeles sinensis) supplementation on lactate accumulation and endurance capacity. Furthermore, we examined CK (creatine kinase), LDH (lactate dehydrogenase) activity to determine whether the HX108-CS affected markers of skeletal muscle injury in vivo and in vitro.

Methods
Exercise capacity was measured by an exhaustive swimming test using ICR mice divided into four groups; one group received distilled water (DW) (Control group, n = 10), and the other groups received three different dosages of HX108-CS (10, 50 and 100 mg/kg, n = 10 per group) solution in water orally. Then, for the time-dependent measurements of blood lactate, CK, and LDH, Sprague–Dawley rats were divided into two groups; one received DW (Control group, n = 10), and the other group received HX108-CS (100 mg/kg, n = 10) solution in the same way as mice. Before the exercise test, the animals were given either DW or HX108-CS for 2 weeks. High-intensity treadmill exercise was performed for 30 minutes. Blood samples were collected and analyzed during and after exercise. For the in vitro experiment, C2C12 cells were treated with HX108-CS to examine its effect on lactate production, CK, and LDH activity.

Results
Blood lactate concentration was significantly lowered immediately after treadmill exercise in HX108-CS group; however, there were no significant differences in activities of CK and LDH between HX108-CS and control during treadmill exercise and recovery phase. Furthermore, treatment with 100 mg/kg of HX108-CS led to a significant increase in the time to exhaustion in swimming test, and concurrently blood lactate concentration was significantly decreased in 50 and 100 mg/kg treated group. Moreover, our results of in vitro experiment showed that HX108-CS suppressed lactate production, CK, and LDH activity in a dose-dependent manner.

Conclusions
These results suggest that supplementation with HX108-CS may enhance exercise capacity by lowering lactate accumulation. This may in part be related to an amelioration of skeletal muscle injury.
Language
English
URI
http://hdl.handle.net/10371/109799
DOI
https://doi.org/10.1186/1550-2783-10-21
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College of Education (사범대학)Dept. of Physical Education (체육교육과)Journal Papers (저널논문_체육교육과)
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