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Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder
DC Field | Value | Language |
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dc.contributor.author | Park, Subin | - |
dc.contributor.author | Kim, Jae-Won | - |
dc.contributor.author | Yang, Young-Hui | - |
dc.contributor.author | Hong, Soon-Beom | - |
dc.contributor.author | Park, Min-Hyeon | - |
dc.contributor.author | Kim, Boong-Nyun | - |
dc.contributor.author | Shin, Min-Sup | - |
dc.contributor.author | Yoo, Hee-Jeong | - |
dc.contributor.author | Cho, Soo-Churl | - |
dc.date.accessioned | 2017-03-17T07:05:11Z | - |
dc.date.available | 2017-03-17T16:21:46Z | - |
dc.date.issued | 2012-05-16 | - |
dc.identifier.citation | Behavioral and Brain Functions, 8(1):22 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109806 | - |
dc.description.abstract | Background
Dysregulation of noradrenergic system may play important roles in pathophysiology of attention-deficit/hyperactivity disorder (ADHD). We examined the relationship between polymorphisms in the norepinephrine transporter SLC6A2 gene and attentional performance before and after medication in children with ADHD. Methods Fifty-three medication-naïve children with ADHD were genotyped and evaluated using the continuous performance test (CPT). After 8-weeks of methylphenidate treatment, these children were evaluated by CPT again. We compared the baseline CPT measures and the post-treatment changes in the CPT measures based on the G1287A and the A-3081T polymorphisms of SLC6A2. Results There was no significant difference in the baseline CPT measures associated with the G1287A or A-3081T polymorphisms. After medication, however, ADHD subjects with the G/G genotype at the G1287A polymorphism showed a greater decrease in the mean omission error scores (p = 0.006) than subjects with the G/A or A/A genotypes, and subjects with the T allele at the A-3081T polymorphism (T/T or A/T) showed a greater decrease in the mean commission error scores (p = 0.003) than those with the A/A genotypes. Conclusions Our results provide evidence for the possible role of the G1287A and A-3081T genotypes of SLC6A2 in methylphenidate-induced improvement in attentional performance and support the noradrenergic hypothesis for the pathophysiology of ADHD. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | SLC6A2 | ko_KR |
dc.subject | Polymorphism | ko_KR |
dc.subject | Continuous performance test | ko_KR |
dc.subject | Methylphenidate | ko_KR |
dc.title | Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박수빈 | - |
dc.contributor.AlternativeAuthor | 김재원 | - |
dc.contributor.AlternativeAuthor | 양영휘 | - |
dc.contributor.AlternativeAuthor | 홍순범 | - |
dc.contributor.AlternativeAuthor | 박민현 | - |
dc.contributor.AlternativeAuthor | 김붕년 | - |
dc.contributor.AlternativeAuthor | 신민섭 | - |
dc.contributor.AlternativeAuthor | 유희정 | - |
dc.contributor.AlternativeAuthor | 조수철 | - |
dc.identifier.doi | 10.1186/1744-9081-8-22 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Park et al.; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-06T10:33:41Z | - |
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