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The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimers disease pathogenesis

DC Field Value Language
dc.contributor.authorKim, Yoonhee-
dc.contributor.authorKim, Chaeyoung-
dc.contributor.authorSon, Sung Min-
dc.contributor.authorSong, Hyundong-
dc.contributor.authorHong, Hyun Seok-
dc.contributor.authorHan, Sun-ho-
dc.contributor.authorMook-Jung, Inhee-
dc.date.accessioned2017-03-20T00:32:49Z-
dc.date.available2017-03-20T09:45:55Z-
dc.date.issued2016-01-12-
dc.identifier.citationMolecular Neurodegeneration, 11(1):4ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/109842-
dc.description.abstractBackground
The receptor for advanced glycation end products (RAGE) has been found to interact with amyloid β (Aβ). Although RAGE does not have any kinase motifs in its cytosolic domain, the interaction between RAGE and Aβ triggers multiple cellular signaling involved in Alzheimers disease (AD). However, the mechanism of signal transduction by RAGE remains still unknown. Therefore, identifying binding proteins of RAGE may provide novel therapeutic targets for AD.

Results
In this study, we identified p38-regulated/activated protein kinase (PRAK) as a novel RAGE interacting molecule. To investigate the effect of Aβ on PRAK mediated RAGE signaling pathway, we treated SH-SY5Y cells with monomeric form of Aβ. We demonstrated that Aβ significantly increased the phosphorylation of PRAK as well as the interaction between PRAK and RAGE. We showed that knockdown of PRAK rescued mTORC1 inactivation induced by Aβ treatment and decreased the formation of Aβ-induced autophagosome.

Conclusions
We provide evidence that PRAK plays a critical role in AD pathology as a key interactor of RAGE. Thus, our data suggest that PRAK might be a potential therapeutic target of AD involved in RAGE-mediated cell signaling induced by Aβ.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectPRAKko_KR
dc.subjectRAGEko_KR
dc.subjectAlzheimer’s diseaseko_KR
dc.subjectAutophagyko_KR
dc.subjectko_KR
dc.titleThe novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimers disease pathogenesisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김윤희-
dc.contributor.AlternativeAuthor김채영-
dc.contributor.AlternativeAuthor손성민-
dc.contributor.AlternativeAuthor송현동-
dc.contributor.AlternativeAuthor홍현석-
dc.contributor.AlternativeAuthor한선호-
dc.contributor.AlternativeAuthor묵정인희-
dc.language.rfc3066en-
dc.rights.holderKim et al.-
dc.date.updated2017-01-06T10:39:15Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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