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Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee Sook | - |
dc.contributor.author | Bae, Taejeong | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Kim, Dae Gyu | - |
dc.contributor.author | Oh, Young Sun | - |
dc.contributor.author | Jang, Yeongjun | - |
dc.contributor.author | Kim, Ji-Tea | - |
dc.contributor.author | Lee, Jong-Jun | - |
dc.contributor.author | Innocenti, Alessio | - |
dc.contributor.author | Supuran, Claudiu T | - |
dc.contributor.author | Chen, Luonan | - |
dc.contributor.author | Rho, Kyoohyoung | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.date.accessioned | 2017-03-20T06:22:36Z | - |
dc.date.available | 2017-03-20T15:27:58Z | - |
dc.date.issued | 2012-07-02 | - |
dc.identifier.citation | BMC Systems Biology, 6(1):80 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109864 | - |
dc.description.abstract | Background
The process of drug discovery and development is time-consuming and costly, and the probability of success is low. Therefore, there is rising interest in repositioning existing drugs for new medical indications. When successful, this process reduces the risk of failure and costs associated with de novo drug development. However, in many cases, new indications of existing drugs have been found serendipitously. Thus there is a clear need for establishment of rational methods for drug repositioning. Results In this study, we have established a database we call PharmDB which integrates data associated with disease indications, drug development, and associated proteins, and known interactions extracted from various established databases. To explore linkages of known drugs to diseases of interest from within PharmDB, we designed the Shared Neighborhood Scoring (SNS) algorithm. And to facilitate exploration of tripartite (Drug-Protein-Disease) network, we developed a graphical data visualization software program called phExplorer, which allows us to browse PharmDB data in an interactive and dynamic manner. We validated this knowledge-based tool kit, by identifying a potential application of a hypertension drug, benzthiazide (TBZT), to induce lung cancer cell death. Conclusions By combining PharmDB, an integrated tripartite database, with Shared Neighborhood Scoring (SNS) algorithm, we developed a knowledge platform to rationally identify new indications for known FDA approved drugs, which can be customized to specific projects using manual curation. The data in PharmDB is open access and can be easily explored with phExplorer and accessed via BioMart web service (http://www.i-pharm.org/, http://biomart.i-pharm.org/). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Tripartite network | ko_KR |
dc.subject | Drug repositioning | ko_KR |
dc.subject | Shared Neighborhood Scoring (SNS) algorithm | ko_KR |
dc.title | Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이희숙 | - |
dc.contributor.AlternativeAuthor | 배태정 | - |
dc.contributor.AlternativeAuthor | 이지현 | - |
dc.contributor.AlternativeAuthor | 김대규 | - |
dc.contributor.AlternativeAuthor | 오영선 | - |
dc.contributor.AlternativeAuthor | 장영준 | - |
dc.contributor.AlternativeAuthor | 김지태 | - |
dc.contributor.AlternativeAuthor | 이종준 | - |
dc.contributor.AlternativeAuthor | 노규형 | - |
dc.contributor.AlternativeAuthor | 김성훈 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Lee et al.; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-06T10:42:13Z | - |
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