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The efficacy and adverse effects of topical phenylephrine for anal incontinence after low anterior resection in patients with rectal cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jun-Seok | - |
dc.contributor.author | Kang, Sung-Bum | - |
dc.contributor.author | Kim, Duck-Woo | - |
dc.contributor.author | Namgung, Hyung-Wook | - |
dc.contributor.author | Kim, Hye-Lin | - |
dc.date.accessioned | 2009-11-03T02:29:08Z | - |
dc.date.available | 2009-11-03T02:29:08Z | - |
dc.date.issued | 2007-06-12 | - |
dc.identifier.citation | Int J Colorectal Dis 22:1319-1324 | en |
dc.identifier.issn | 0179-1958 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17569063 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11036 | - |
dc.description.abstract | BACKGROUND: Anal incontinence is experienced by some patients with rectal cancer who received low anterior resection. This study was to examine the efficacy and adverse effects of the alpha-1 adrenergic agonist phenylephrine, which causes contraction of the internal anal sphincter and raises the resting pressure in these patients. PATIENTS AND METHODS: Thirty-five patients with anal incontinence were treated with 30% phenylephrine or a placebo randomly allocated in a double-blind study. The efficacy of the drug was assessed by changes in the following standardized questionnaire scores: the fecal incontinence severity index (FISI), fecal incontinence quality of life (FIQL) scales, and a global efficacy question. Anal sphincter function was evaluated using anorectal manometry. RESULTS: Phenylephrine did not improve either the FISI score or any of the four FIQL scores. Five of 17 (29%) patients reported subjective improvement after phenylephrine compared with 4 of 12 (33%) using the placebo. The maximum resting anal pressure did not differ between baseline and after 4 weeks application of phenylephrine (30.0 to 27.3 mmHg). In the phenylephrine group, allergic dermatitis was developed in five patients and headache in two. CONCLUSION: In the patients with anal incontinence after low anterior resection for rectal cancer, phenylephrine gel did not seem to be helpful in relieving symptoms with some adverse effects. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Anal incontinence | en |
dc.subject | Low anterior resection | en |
dc.subject | Phenylephrine | en |
dc.subject | Rectal cancer | en |
dc.title | The efficacy and adverse effects of topical phenylephrine for anal incontinence after low anterior resection in patients with rectal cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박준석 | - |
dc.contributor.AlternativeAuthor | 강성범 | - |
dc.contributor.AlternativeAuthor | 김덕우 | - |
dc.contributor.AlternativeAuthor | 남궁형욱 | - |
dc.contributor.AlternativeAuthor | 김혜린 | - |
dc.identifier.doi | 10.1007/s00384-007-0335-6 | - |
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