S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
G-CSF protects human cerebral hybrid neurons against in vitro ischemia
- Jung, Keun-Hwa; Chu, Kon; Lee, Soon-Tae; Kang, Lami; Kim, Seung U.; Kim, Manho; Roh, Jae-Kyu
- Issue Date
- Neurosci. Lett. 394 (2006) 168-173
- Granulocyte colony-stimulating factor (G-CSF) protects neurons against experimental focal cerebral ischemia. However, its neuroprotective effect on human brain is unknown. We sought to determine whether G-CSF can protect the human cerebral neurons in vitro. Human cerebral-neuroblastoma hybrid cell line (A1) was exposed to oxygen and glucose deprivation with or without G-CSF. G-CSF promoted cell survival and decreased cytotoxicity effectively at 25 ng/ml. G-CSF reduced early apoptotic (annexin V+/PI-), and late apoptotic or necrotic (annexin V+/PI+) cells, and decreased active caspase-3 immunoreactivity. G-CSF could protect human cerebral neurons following in vitro ischemia.
- 0304-3940 (Print)
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