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G-CSF protects human cerebral hybrid neurons against in vitro ischemia
Cited 26 time in
Web of Science
Cited 32 time in Scopus
- Authors
- Issue Date
- 2006
- Publisher
- Elsevier
- Citation
- Neurosci. Lett. 394 (2006) 168-173
- Keywords
- G-CSF ; Ischemia ; Neuronal death ; Neuroprotection ; G-CSFR ; STAT3
- Abstract
- Granulocyte colony-stimulating factor (G-CSF) protects neurons against experimental focal cerebral ischemia. However, its neuroprotective effect on human brain is unknown. We sought to determine whether G-CSF can protect the human cerebral neurons in vitro. Human cerebral-neuroblastoma hybrid cell line (A1) was exposed to oxygen and glucose deprivation with or without G-CSF. G-CSF promoted cell survival and decreased cytotoxicity effectively at 25 ng/ml. G-CSF reduced early apoptotic (annexin V+/PI-), and late apoptotic or necrotic (annexin V+/PI+) cells, and decreased active caspase-3 immunoreactivity. G-CSF could protect human cerebral neurons following in vitro ischemia.
- ISSN
- 0304-3940 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16298488
https://hdl.handle.net/10371/11094
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