Browse

Reduction of plasma homocysteine by folic acid in children with chronic renal failure

DC Field Value Language
dc.contributor.authorKang, Hee Gyung-
dc.contributor.authorLee, Byong Sop-
dc.contributor.authorHahn, Hyewon-
dc.contributor.authorLee, Jun Ho-
dc.contributor.authorHa, Il Soo-
dc.contributor.authorCheong, Hae Il-
dc.contributor.authorChoi, Yong-
dc.date.accessioned2009-11-04T06:23:40Z-
dc.date.available2009-11-04T06:23:40Z-
dc.date.issued2002-
dc.identifier.citationPediatr Nephrol 17:511-514en
dc.identifier.issn0931-041X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12172764-
dc.identifier.urihttp://hdl.handle.net/10371/11119-
dc.description.abstractHyperhomocysteinemia is a well-known independent risk factor for cardiovascular disease and is a prevalent abnormality in chronic renal failure. However, studies on this abnormality in children with chronic renal failure, before renal replacement therapy, are scarce. In this study, we measured the plasma homocysteine levels of 27 children (mean age 8.9+/-4.8 years) with predialytic chronic renal failure, and analyzed the effect of folic acid supplementation (1 mg daily for 4 weeks) on the homocysteine levels in 14 of these children. The baseline homocysteine concentration of the patients (12.5+/-6.0 micro mol/l) was higher than that of the control group (5.9+/-1.8 micro mol/l, P<0.001), and correlated positively with age and negatively with folic acid concentration. Folic acid and vitamin B(12) concentrations were not below normal in any patient. The homocysteine concentration was decreased from 13.2+/-6.6 micro mol/l (pretreatment) to 9.3+/-4.2 micro mol/l by folic acid supplementation in the 14 patients. Folic acid supplementation also lowered the prevalence of hyperhomocysteinemia from 64.3% to 42.9%. According to these results, we recommend that folic acid supplementation be started in children with chronic renal failure early in the disease course.en
dc.description.sponsorshipThis study was supported in part by year
2001 BK21 project for Medicine, Dentistry, and Pharmacy in
Korea.
en
dc.language.isoen-
dc.publisherSpringer Verlagen
dc.subjectChronic renal failureen
dc.subjectFolic aciden
dc.subjectHomocysteineen
dc.subjectPredialysisen
dc.titleReduction of plasma homocysteine by folic acid in children with chronic renal failureen
dc.typeArticleen
dc.contributor.AlternativeAuthor강희경-
dc.contributor.AlternativeAuthor이병섭-
dc.contributor.AlternativeAuthor한혜원-
dc.contributor.AlternativeAuthor이준호-
dc.contributor.AlternativeAuthor하일수-
dc.contributor.AlternativeAuthor정해일-
dc.contributor.AlternativeAuthor최용-
dc.identifier.doi10.1007/s00467-002-0864-8-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse