Publications
Detailed Information
Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 2007
- Publisher
- American Association of Immunologists
- Citation
- J. Immunol. 179, 5897-5906
- Keywords
- Cell Differentiation ; Chemokine CCL19/genetics/*metabolism ; Chemokine CCL21/genetics/*metabolism ; DNA/genetics ; Dendritic Cells/cytology ; Hypersensitivity/metabolism/pathology ; Immunoglobulin E/biosynthesis/immunology ; Lymphocyte Count ; Lymphoid Tissue/*metabolism ; Mice, Inbred BALB C ; Rhinitis/*metabolism/pathology ; T-Lymphocytes, Regulatory/cytology ; Th1 Cells/metabolism ; Th2 Cells/metabolism
- Abstract
- The lymphoid chemokines CCL19 and CCL21 are known to be crucial both for lymphoid cell trafficking and for the structural organization of lymphoid tissues such as nasopharynx-associated lymphoid tissue (NALT). However, their role in allergic responses remains unclear, and so our current study aims to shed light on the role of CCL19/CCL21 in the development of allergic rhinitis. After nasal challenge with OVA, OVA-sensitized plt (paucity of lymph node T cells) mice, which are deficient in CCL19/CCL21, showed more severe allergic symptoms than did identically treated wild-type mice. OVA-specific IgE production, eosinophil infiltration, and Th2 responses were enhanced in the upper airway of plt mice. Moreover, in plt mice, the number of CD4(+)CD25(+) regulatory T cells declined in the secondary lymphoid tissues, whereas the number of Th2-inducer-type CD8alpha(-)CD11b(+) myeloid dendritic cells (m-DCs) increased in cervical lymph nodes and NALT. Nasal administration of the plasmid-encoding DNA of CCL19 resulted in the reduction of m-DCs in the secondary lymphoid tissues and the suppression of allergic responses in plt mice. These results suggest that CCL19/CCL21 act as regulatory chemokines for the control of airway allergic disease and so may offer a new strategy for the control of allergic disease.
- ISSN
- 0022-1767 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17947663
https://hdl.handle.net/10371/11165
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.