S-Space College of Medicine/School of Medicine (의과대학/대학원) Otorhinolaryngology (이비인후과학전공) Journal Papers (저널논문_이비인후과학전공)
Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis
- Takamura, Kaoru; Fukuyama, Satoshi; Nagatake, Takahiro; Kim, Dong-Young; Kawamura, Aya; Kawauchi, Hideyuki; Kiyono, Hiroshi
- Issue Date
- American Association of Immunologists
- J. Immunol. 179, 5897-5906
- Cell Differentiation; Chemokine CCL19/genetics/*metabolism; Chemokine CCL21/genetics/*metabolism; DNA/genetics; Dendritic Cells/cytology; Hypersensitivity/metabolism/pathology; Immunoglobulin E/biosynthesis/immunology; Lymphocyte Count; Lymphoid Tissue/*metabolism; Mice, Inbred BALB C; Rhinitis/*metabolism/pathology; T-Lymphocytes, Regulatory/cytology; Th1 Cells/metabolism; Th2 Cells/metabolism
- The lymphoid chemokines CCL19 and CCL21 are known to be crucial both for lymphoid cell trafficking and for the structural organization of lymphoid tissues such as nasopharynx-associated lymphoid tissue (NALT). However, their role in allergic responses remains unclear, and so our current study aims to shed light on the role of CCL19/CCL21 in the development of allergic rhinitis. After nasal challenge with OVA, OVA-sensitized plt (paucity of lymph node T cells) mice, which are deficient in CCL19/CCL21, showed more severe allergic symptoms than did identically treated wild-type mice. OVA-specific IgE production, eosinophil infiltration, and Th2 responses were enhanced in the upper airway of plt mice. Moreover, in plt mice, the number of CD4(+)CD25(+) regulatory T cells declined in the secondary lymphoid tissues, whereas the number of Th2-inducer-type CD8alpha(-)CD11b(+) myeloid dendritic cells (m-DCs) increased in cervical lymph nodes and NALT. Nasal administration of the plasmid-encoding DNA of CCL19 resulted in the reduction of m-DCs in the secondary lymphoid tissues and the suppression of allergic responses in plt mice. These results suggest that CCL19/CCL21 act as regulatory chemokines for the control of airway allergic disease and so may offer a new strategy for the control of allergic disease.
- 0022-1767 (Print)
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