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3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences

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dc.contributor.authorKim, J. H.-
dc.contributor.authorChang, K. H.-
dc.contributor.authorNa, D. G.-
dc.contributor.authorSong, I. C.-
dc.contributor.authorKwon, B. J.-
dc.contributor.authorHan, M. H.-
dc.contributor.authorKim, K.-
dc.date.accessioned2009-11-04T22:29:51Z-
dc.date.available2009-11-04T22:29:51Z-
dc.date.issued2006-
dc.identifier.citationAJNR Am J Neuroradiol 2006;27:1412-8en
dc.identifier.issn0195-6108 (Print)-
dc.identifier.issn1936-959X (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16908549-
dc.identifier.urihttps://hdl.handle.net/10371/11172-
dc.description.abstractBACKGROUND AND PURPOSE: Echo time (TE) can have a large influence on the spectra in proton MR spectroscopy ((1)H-MR spectroscopy). The purpose of this study was to comparatively assess the diagnostic value of 3T single-voxel (1)H-MR spectroscopy with short or intermediate TEs in grading cerebral gliomas. METHODS: Single voxel (1)H-MR spectroscopy was performed at 3T in 35 patients with cerebral glioma. The spectra were obtained with both short (35 ms) and intermediate TEs (144 ms). Metabolite ratios of choline (Cho)/creatine (Cr), Cho/N-acetylaspartate (NAA), lipid and lactate (LL)/Cr and myo-inositol (mIns)/Cr were calculated and compared between short and intermediate TEs in each grade. After receiver operating characteristic curve analysis, diagnostic accuracy for each TE in differentiating high-grade glioma from low-grade glioma was compared. RESULTS: At short TE, Cho/Cr and Cho/NAA ratios were significantly lower, and LL/Cr and mIns/Cr were significantly higher, compared with those at intermediate TE, regardless of tumor grade. Lactate inversion at intermediate TE was found in only 2 patients. At both TEs, there were significant differences in Cho/Cr and LL/Cr ratios between low- and high-grade gliomas. Diagnostic accuracy was slightly higher at short TE alone or combined with intermediate TE than intermediate TE alone (85.7% versus 82.9%). CONCLUSION: Metabolite ratios were significantly different between short and intermediate TE. Cho/Cr and LL/Cr ratios at either TE were similarly useful in differentiating high-grade gliomas from low-grade gliomas. If only a single spectroscopic sequence can be acquired, short TE seems preferable because of poor lactate inversion at intermediate TE on 3T single-voxel (1)H-MR spectroscopy.en
dc.language.isoen-
dc.publisherAmerican Society of Neuroradiologyen
dc.subjectAspartic Acid/analogs & derivatives/analysisen
dc.subjectBrain Neoplasms/*diagnosisen
dc.subjectCholine/analysisen
dc.subjectCreatine/analysisen
dc.subjectEcho-Planar Imaging/methodsen
dc.subjectGlioma/*diagnosisen
dc.subjectHydrogenen
dc.subjectImage Enhancement/methodsen
dc.subjectInositol/analysisen
dc.subjectLactates/analysisen
dc.subjectLipids/analysisen
dc.subjectMagnetic Resonance Spectroscopy/*methodsen
dc.subjectPhosphocreatine/analysisen
dc.subjectTime Factorsen
dc.title3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequencesen
dc.typeArticleen
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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