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Changes in P2Y4 receptor expression in rat cochlear outer sulcus cells during development

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dc.contributor.authorLee, Jun Ho-
dc.contributor.authorHeo, Jeong-Hwa-
dc.contributor.authorKim, Chang-Hee-
dc.contributor.authorChang, Sun O-
dc.contributor.authorKim, Chong-Sun-
dc.contributor.authorOh, Seung-Ha-
dc.date.accessioned2009-11-04T22:38:04Z-
dc.date.available2009-11-04T22:38:04Z-
dc.date.issued2007-04-17-
dc.identifier.citationHear. Res. 228, 201-211en
dc.identifier.issn0378-5955 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17433586-
dc.identifier.urihttp://hdl.handle.net/10371/11176-
dc.description.abstractExtracellular adenosine triphosphate (ATP) released from cellular sources plays an important role in variety of the cochlear physiologic processes. The primary purinergic receptor subtype in the cochlea is the P2X2 receptor, which is a subtype of P2X receptor. This receptor appears to mediate a protective decrease in the electrical driving force in response to acoustic overstimulation. Outer sulcus cells (OSCs) in the cochlear lateral wall appear to maintain an adequate K+ concentration in the cochlear endolymph in response to varying intensities of auditory stimulation. However, little is known about developing OSCs. The purpose of this study was to investigate subtypes of purinergic receptors in developing rat OSCs using a voltage-sensitive vibrating probe. Results showed that only two P2 receptors (P2Y4 and P2X2) contributed to the regulation of short circuit currents in neonatal OSCs. ATP increased cation absorption via apical nonselective cation channels after activating P2Y4 receptors in early neonatal OSCs. P2Y4 expression rapidly declined postnatally and reached near adult levels on postnatal day 14. P2X2 was co-expressed with P2Y4 in early neonatal OSCs. Temporal changes in P2Y4 during OSC development might be involved in the establishment of the endolymphatic ion composition needed for normal auditory transduction and/or specific cellular differentiation.en
dc.description.sponsorshipThis work was supported by the
Clinical Research Institute at Seoul National University
Hospital (Grant No. 03-2004-032).
en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectVoltage-sensitive vibrating probeen
dc.subjectPurinergic receptoren
dc.subjectOuter sulcus cellen
dc.subjectInner earen
dc.subjectEndolymphen
dc.titleChanges in P2Y4 receptor expression in rat cochlear outer sulcus cells during developmenten
dc.typeArticleen
dc.contributor.AlternativeAuthor이준호-
dc.contributor.AlternativeAuthor허정화-
dc.contributor.AlternativeAuthor김창희-
dc.contributor.AlternativeAuthor장선오-
dc.contributor.AlternativeAuthor김종선-
dc.contributor.AlternativeAuthor오승하-
dc.identifier.doi10.1016/j.heares.2007.02.008-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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