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Effects of purinergic stimulation on ciliary beat frequency and chloride secretion in sinusitis

DC Field Value Language
dc.contributor.authorKim, In-Sang-
dc.contributor.authorRhee, Chae-Seo-
dc.contributor.authorLee, Jun Ho-
dc.contributor.authorHeo, Jeong-Hwa-
dc.contributor.authorPark, Jerry-
dc.contributor.authorLee, Chul Hee-
dc.date.accessioned2009-11-04T23:00:16Z-
dc.date.available2009-11-04T23:00:16Z-
dc.date.issued2007-
dc.identifier.citationLaryngoscope 2007;117:1677-1682en
dc.identifier.issn0023-852X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17632427-
dc.identifier.urihttp://hdl.handle.net/10371/11186-
dc.description.abstractOBJECTIVES: We aimed to identify the functional abnormality of sinusitis-affected mucosa by observing the responsiveness of the mucosa to purinergic stimulation after the onset of sinusitis and during the recovery period. We also aimed to identify possible beneficial effects of purinergic agonists on sinusitis. METHODS: A rabbit sinusitis model was developed by blocking maxillary ostia. Sinus mucosae were harvested immediately and 1 and 4 weeks after reopening the ostia. We measured chloride secretion and ciliary beat frequencies responding to purinergic stimulation. RESULTS: The increases of ciliary beat frequency by adenosine triphosphate (100 micromol/L) were 3.2%+/-8.5%, 7.9%+/-2.3%, and 12.2%+/-1.9% immediately after establishment of sinusitis and 1 week and 4 weeks after reopening of ostia, respectively. Chloride secretion stimulated by adenosine triphosphate also showed gradual increase during the recovery period. Grossly, the mucosae appeared to have normalized in 80% (4 of 5) after 4 weeks; however, functional and microscopic improvements were still incomplete. CONCLUSIONS: Mucosal functions, assessed by increase of ciliary activity and ion secretion by purinergic stimulation, and microscopic findings showed gradual but incomplete recovery after 4 weeks of recovery, in contrast to the gross normalization. Purinergic agonists may have beneficial effects on sinusitis by stimulating decreased ciliary motility and chloride secretion in sinusitis.en
dc.language.isoenen
dc.publisherLaryngoscopeen
dc.subjectSinusitisen
dc.subjectpurinergic receptorsen
dc.subjectchloride channelsen
dc.subjectmucociliary clearanceen
dc.titleEffects of purinergic stimulation on ciliary beat frequency and chloride secretion in sinusitisen
dc.typeArticleen
dc.contributor.AlternativeAuthor김인상-
dc.contributor.AlternativeAuthor이재서-
dc.contributor.AlternativeAuthor이준호-
dc.contributor.AlternativeAuthor허정화-
dc.contributor.AlternativeAuthor이철희-
dc.identifier.doi10.1097/MLG.0b013e31806911cc-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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