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Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating TGF-Beta signaling in aged human skin in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Eui Dong | - |
dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Lee, Serah | - |
dc.contributor.author | Kim, Mi Sun | - |
dc.contributor.author | Lee, Byeong Gon | - |
dc.contributor.author | Chang, Ih Seoup | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.date.accessioned | 2009-11-09T03:11:24Z | - |
dc.date.available | 2009-11-09T03:11:24Z | - |
dc.date.issued | 2005-06-16 | - |
dc.identifier.citation | J Invest Dermatol. 2005 Jun;124(6):1149-61. | en |
dc.identifier.issn | 0022-202X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15955089 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11561 | - |
dc.description.abstract | To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo. In addition, metalloproteinase (MMP-1 protein levels were reduced by topical 17beta-estradiol. The expressions of TGF-beta1, TGF-beta type II receptor, and Sma and Mad related (Smad)3 were increased by topical 17 beta-estradiol in aged human skin, and TGF-beta1 neutralizing antibody inhibited 17beta-estradiol-induced procollagen synthesis in cultured fibroblasts. We also found that the expressions of tropoelastin and fibrillin-1 mRNA and protein, and elastic fibers in aged skin were also increased by topical 17beta-estradiol. Topical 17beta-estradiol also increased keratinocyte proliferation and the epidermal thickness in aged human skin. We also observed the same effects of topical 17beta-estradiol in young skin. In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness. | en |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | en |
dc.subject | Administration, Topical | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Antibodies/pharmacology | en |
dc.subject | Cell Proliferation/drug effects | en |
dc.subject | Collagen Type I/antagonists & inhibitors/genetics/metabolism | en |
dc.subject | DNA-Binding Proteins/genetics/metabolism | en |
dc.subject | Estradiol/*administration & dosage/pharmacology | en |
dc.subject | Extracellular Matrix Proteins/*biosynthesis | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Keratinocytes/cytology | en |
dc.subject | Male | en |
dc.subject | Matrix Metalloproteinase 1/metabolism | en |
dc.subject | Microfilament Proteins/genetics/metabolism | en |
dc.subject | Middle Aged | en |
dc.subject | Protein-Serine-Threonine Kinases | en |
dc.subject | RNA, Messenger/metabolism | en |
dc.subject | Receptors, Transforming Growth Factor beta/metabolism | en |
dc.subject | Signal Transduction/*physiology | en |
dc.subject | Skin Aging/*physiology | en |
dc.subject | Smad3 Protein | en |
dc.subject | Smad7 Protein | en |
dc.subject | Trans-Activators/genetics/metabolism | en |
dc.subject | Transforming Growth Factor beta/genetics/immunology/*metabolism | en |
dc.subject | Transforming Growth Factor beta1 | en |
dc.subject | Tropoelastin/genetics/metabolism | en |
dc.title | Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating TGF-Beta signaling in aged human skin in vivo | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 손의동 | - |
dc.contributor.AlternativeAuthor | 이진영 | - |
dc.contributor.AlternativeAuthor | 이세라 | - |
dc.contributor.AlternativeAuthor | 김미선 | - |
dc.contributor.AlternativeAuthor | 이병곤 | - |
dc.contributor.AlternativeAuthor | 장인섭 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1111/j.0022-202X.2005.23736.x | - |
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