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Monitoring transplanted human mesenchymal stem cells in rat and rabbit bladders using molecular magnetic resonance imaging
DC Field | Value | Language |
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dc.contributor.author | Song, Yun Seob | - |
dc.contributor.author | Ku, Ja Hyeon | - |
dc.date.accessioned | 2009-11-09T06:06:07Z | - |
dc.date.available | 2009-11-09T06:06:07Z | - |
dc.date.issued | 2007-03-16 | - |
dc.identifier.citation | Neurourol Urodyn. 2007;26(4):584-93. | en |
dc.identifier.issn | 0733-2467 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17357122 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11575 | - |
dc.description.abstract | AIMS: This study investigated whether superparamagnetic iron oxide (SPIO)-labeled human mesenchymal stem cells (hMSCs) may be monitored non-invasively by in vivo magnetic resonance (MR) imaging with conventional 1.5-T system examinations in the bladders of rats and rabbits. METHODS: SPIO were transferred to hMSCs, using GenePORTER. After SPIO-labeled hMSCs were transplanted into the animal bladders, serial T2-weighted MR images and histological examinations were performed over a 4-week period. RESULTS: hMSCs loaded with SPIO, compared to unlabeled cells, showed similar viability. SPIO-labeled hMSCs underwent normal chondrogenic, adipogenic, and osteogenic differentiation. For SPIO-labeled hMSCs concentrations that were greater than 1x10(5), in vitro MR images showed a decrease in signal intensity. MR signal intensity at the areas of SPIO-labeled hMSCs in rat and rabbit bladders were decreased and confined locally. After injection of SPIO-labeled hMSCs into the bladder, MR imaging demonstrated that hMSCs could be seen for at least 12 weeks post-injection. The presence of iron was confirmed with Prussian blue staining in histological sections. CONCLUSIONS: Our findings suggest that hMSCs in animal bladders can be monitored non-invasively with conventional MR imaging. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adipocytes/physiology | en |
dc.subject | Animals | en |
dc.subject | Cell Differentiation/physiology | en |
dc.subject | Cell Survival/physiology | en |
dc.subject | Chondrocytes/physiology | en |
dc.subject | Ferric Compounds/diagnostic use | en |
dc.subject | Humans | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Nanoparticles/diagnostic use | en |
dc.subject | Osteocytes/physiology | en |
dc.subject | Rabbits | en |
dc.subject | Rats | en |
dc.subject | Urinary Bladder/*cytology/*physiology | en |
dc.subject | Mesenchymal Stem Cell Transplantation | - |
dc.title | Monitoring transplanted human mesenchymal stem cells in rat and rabbit bladders using molecular magnetic resonance imaging | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 송윤섭 | - |
dc.contributor.AlternativeAuthor | 구자현 | - |
dc.identifier.doi | 10.1002/nau.20351 | - |
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