Publications
Detailed Information
A haplotype analysis of HER-2 gene polymorphisms: association with breast cancer risk, HER-2 protein expression in the tumor, and disease recurrence in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Choi, Ji-Yeob | - |
dc.contributor.author | Lee, Kyung-Mu | - |
dc.contributor.author | Bae, Ji Yeon | - |
dc.contributor.author | Kim, Sook | - |
dc.contributor.author | Shin, Eun-Soon | - |
dc.contributor.author | Lee, Jeong Eon | - |
dc.contributor.author | Shin, Hyuk-Jae | - |
dc.contributor.author | Kim, Seok Won | - |
dc.contributor.author | Kim, Sung-Won | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.date.accessioned | 2009-11-09T06:20:46Z | - |
dc.date.available | 2009-11-09T06:20:46Z | - |
dc.date.issued | 2005-07-08 | - |
dc.identifier.citation | Clin Cancer Res. 2005 Jul 1;11(13):4775-8 | en |
dc.identifier.issn | 1078-0432 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16000574 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11584 | - |
dc.description.abstract | PURPOSE: A single-nucleotide polymorphism (SNP) in codon 655 of HER-2 has been extensively studied with inconclusive results. The purpose of this study was to investigate the association between common variants of HER-2 and breast cancer risk, HER-2 expression, and survival using a haplotype-based stepwise approach. EXPERIMENTAL DESIGN: Twenty-nine SNPs listed in the National Center for Biotechnology Information database were screened to identify novel polymorphisms of HER-2 gene in 90 healthy Korean women. Six of 29 SNPs were polymorphic and had greater than 10% of minor allele frequencies. Using these six SNPs, linkage disequilibrium and haplotype patterns were characterized. We tested association between the haplotypes and breast cancer in a large case-control study (n=1,039 cases and 995 controls). Six-hundred two breast cancer patients with follow-up at least 24 months were analyzed for outcome in relation to haplotype. Expression of HER-2 protein was determined by immunohistochemistry in 1,094 cases of invasive breast cancer. RESULTS: All six SNPs showed a strong linkage disequilibrium pattern and were considered to belong to one haplotype block. Two haplotype-tagging SNPs (I655V and P1170A) for three common haplotypes (>5%) were genotyped in cases and controls. The haplotypes and individual SNPs were not associated with breast cancer risk. In patients with at least one copy of haplotype I (the most common haplotype), HER-2 expression was 1.5 times higher (P = 0.009) and the prognosis was worse (P = 0.032) compared with patients without having that haplotype. CONCLUSIONS: Our results suggest that the currently identified genetic polymorphisms of HER-2 are not associated with an increased risk of breast cancer in Korean women, whereas one haplotype does affect protein expression of the tumor and disease outcome. | en |
dc.language.iso | en | - |
dc.publisher | American Association for Cancer Research | en |
dc.subject | Adult | en |
dc.subject | Alleles | en |
dc.subject | Breast Neoplasms/genetics/metabolism/*pathology | en |
dc.subject | Case-Control Studies | en |
dc.subject | Disease-Free Survival | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Haplotypes/*genetics | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Korea | en |
dc.subject | Linkage Disequilibrium | en |
dc.subject | Lymphatic Metastasis | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Recurrence, Local | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Prognosis | en |
dc.subject | Receptor, erbB-2/*genetics/metabolism | en |
dc.subject | Risk Factors | en |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | A haplotype analysis of HER-2 gene polymorphisms: association with breast cancer risk, HER-2 protein expression in the tumor, and disease recurrence in Korea | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 박인애 | - |
dc.contributor.AlternativeAuthor | 최지엽 | - |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 배지연 | - |
dc.contributor.AlternativeAuthor | 김숙 | - |
dc.contributor.AlternativeAuthor | 신은순 | - |
dc.contributor.AlternativeAuthor | 이정언 | - |
dc.contributor.AlternativeAuthor | 신혁재 | - |
dc.contributor.AlternativeAuthor | 김석원 | - |
dc.contributor.AlternativeAuthor | 김성원 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-04-2208 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.