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Pharmacokinetic study of meropenem in healthy beagle dogs receiving intermittent hemodialysis

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Byun, Seok-Yeong; Jeong, Jong-Woo; Choi, Joon-Hyuk; Lee, K. P.; Youn, Hwa-Young; Maeng, H. J.; Song, K. H.; Koo, Tae-Sung; Seo, Kyoung-Won
Issue Date
2016-12
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS Vol.39 No.6, pp. 560-565
Keywords
Pharmacokinetic study of meropenem in healthy beagle dogs receiving intermittent hemodialysis복합학
Abstract
Meropenem, a second carbapenem antimicrobial agent with a broad spectrum of activity, is used to treat sepsis and resistant-bacterial infections in veterinary medicine. The objective of this study was to identify the pharmacokinetics of meropenem in dogs receiving intermittent hemodialysis (IHD) and to determine the proper dosing in renal failure patients receiving IHD. Five healthy beagle dogs were given a single i.v. dose of 24 mg/kg of meropenem and received IHD. The blood flow rate, dialysate flow, and ultrafiltration rate were maintained at 40 mL/min, 300 mL/min, and 40 mL/h, respectively. Blood samples were collected for 24 h from the jugular vein and from the extracorporeal arterial and venous line. Urine samples and dialysate were also collected. The concentrations of meropenem were assayed using HPLC/MS/MS determination. The peak plasma concentration was 116 +/- 37 mu g/mL at 15 min. The systemic clearance was 347 +/- 117 mL/h/kg, and the steady-state volume of distribution was 223 +/- 67 mL/kg. Dialysis clearance was 71.1 +/- 34.3 mL/h/kg, and the extraction ratio by hemodialysis was 0.455 +/- 0.150. The half-life (T-1/2) in dogs with IHD decreased compared with those without IHD, and the reduction in T1/2 was greater in renal failure patients than in normal patients. Sixty-nine percent and 21% of the administered drug were recovered by urine and dialysate in the unchanged form, respectively. In conclusion, additional dosing of 24 mg/kg of meropenem after dialysis could be necessary according to the residual renal function of the patient based on the simulated data.
ISSN
0140-7783
Language
English
URI
http://hdl.handle.net/10371/116904
DOI
https://doi.org/10.1111/jvp.12326
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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