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Role of Arachidonic Acid in Promoting Hair Growth
26848219

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dc.contributor.authorMunkhbayar, Semchinen
dc.contributor.authorJang, Sunhyae-
dc.contributor.authorCho, A-Ri-
dc.contributor.authorChoi, Soon-Jin-
dc.contributor.authorShin, Chang Yup-
dc.contributor.authorEun, Hee Chul-
dc.contributor.authorKim, Kyu Han-
dc.contributor.authorKwon, Ohsang-
dc.date.accessioned2017-04-19T00:45:46Z-
dc.date.available2017-07-30T22:00:34Z-
dc.date.issued2015-05-21-
dc.identifier.citationANNALS OF DERMATOLOGY Vol.28 No.1, pp. 55-64-
dc.identifier.issn1013-9087-
dc.identifier.urihttps://hdl.handle.net/10371/116923-
dc.description.abstractBackground: Arachidonic acid (AA) is an omega-6 polyunsaturated fatty acid present in all mammalian cell membranes, and involved in the regulation of many cellular processes, including cell survival, angiogenesis, and mitogenesis. The dermal papilla, composed of specialized fibroblasts located in the bulb of the hair follicle, contributes to the control of hair growth and the hair cycle.
Objective: This study investigated the effect of AA on hair growth by using in vivo and in vitro models.
Methods: The effect of AA on. human dermal papilla cells (hDPCs) and hair shaft elongation was evaluated by MTT assay and hair follicle organ culture, respectively. The expression of various growth and survival factors in hDPCs were investigated by western blot or immunohistochemistry. The ability of AA to induce and prolong anagen phase in C57BL/6 mice was analyzed.
Results: AA was found to enhance the viability of hDPCs and promote the expression of several factors responsible for hair growth, including fibroblast growth factor-7 (FGF-7) and FGF-10. Western blotting identified the role of AA in the phosphorylation of various transcription factors (ERK, CREB, and AKT) and increased expression of Bcl-2 in hDPCs. In addition, AA significantly promoted hair shaft elongation, with increased proliferation of matrix keratinocytes, during ex vivo hair follicle culture. It was also found to promote hair growth by induction and prolongation of anagen phase in telogen-stage C57BL/6 mice.
Conclusion: This study concludes that AA plays a role in promoting hair growth by increasing the expression of growth factors in hDPCs and enhancing follicle proliferation and survival.
en
dc.language.isoenen
dc.publisherKOREAN DERMATOLOGICAL ASSOCIATIONen
dc.subjectArachidonic aciden
dc.subjectHairen
dc.subjectHair follicle-
dc.titleRole of Arachidonic Acid in Promoting Hair Growthen
dc.title.alternative26848219en
dc.typeArticleen
dc.contributor.AlternativeAuthor장선혜-
dc.contributor.AlternativeAuthor조아리-
dc.contributor.AlternativeAuthor최순진-
dc.contributor.AlternativeAuthor신창엽-
dc.contributor.AlternativeAuthor은희철-
dc.contributor.AlternativeAuthor김규한-
dc.contributor.AlternativeAuthor권오상-
dc.identifier.doi10.5021/ad.2016.28.1.55-
dc.description.srndOAIID:RECH_ACHV_DSTSH_NO:220160000045457003-
dc.description.srndRECH_ACHV_FG:RR00200001-
dc.description.srndADJUST_YN:-
dc.description.srndEMP_ID:A079130-
dc.description.srndCITE_RATE:1.325-
dc.description.srndFILENAME:ann dermatol 2016.pdf-
dc.description.srndDEPT_NM:의학과-
dc.description.srndEMAIL:oskwon@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/4a68686a-75a8-4da6-a12f-200fb2e66485/link-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd220160000045457003-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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