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Plasma glutathione reductase activity and prognosis of septic shock : 26316444
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae Seong | en |
dc.contributor.author | Kwon, Woon Yong | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kim, Kyung Su | - |
dc.contributor.author | Jung, Yoon Sun | - |
dc.contributor.author | Kim, Sung Hee | - |
dc.contributor.author | Lee, So Eun | - |
dc.date.accessioned | 2017-04-19T00:45:48Z | - |
dc.date.available | 2017-07-30T20:28:57Z | - |
dc.date.issued | 2015-08-05 | - |
dc.identifier.citation | JOURNAL OF SURGICAL RESEARCH Vol.200 No.1, pp. 298-307 | - |
dc.identifier.issn | 0022-4804 | - |
dc.identifier.uri | https://hdl.handle.net/10371/116924 | - |
dc.description.abstract | Background: Our aim was to investigate whether plasma glutathione reductase (GR) activity is well correlated with the erythrocyte-reduced glutathione (GSH)/glutathione disulfide (GSSG) ratio and is associated with the mortality of septic shock.
Materials and methods: This study was conducted on male Sprague-Dawley rats and patients admitted to the intensive care unit with septic shock. To induce endotoxemia in rats, vehicle or lipopolysaccharide (LPS) at dosages of 5 or 10 mg/kg were injected into a tail vein. Animals were then euthanized 6 h post-LPS. Based on the 28-d mortality, the enrolled patients were divided into the survivors and nonsurvivors. We obtained blood samples from patients at admission (0 h) and 24 h after admission to the intensive care unit. Results: In endotoxemic rats, the erythrocyte GSH/GSSG ratio, erythrocyte GR activity, and plasma GR activity in the 10 mg/kg of LPS group were lower than those in the sham and 5 mg/kg of LPS groups. In patients with septic shock, decrease in plasma GR activity at 24 h was independently associated with an increase in 28-d mortality (odds ratio, 0.828; 95% confidence interval, 0.690-0.992, P ¼ 0.041). Plasma GR activity was correlated with erythrocyte GR activity (Spearman r ¼ 0.549, P < 0.001) and the erythrocyte GSH/GSSG ratio (rho ¼ 0.367, P ¼ 0.009) at 24 h. Conclusions: Plasma GR activity was well correlated with erythrocyte GR activity and the erythrocyte GSH/GSSG ratio, and a decrease in plasma GR activity was associated with an increase in the mortality of septic shock patients. | - |
dc.language.iso | en | en |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en |
dc.subject | Septic shock | en |
dc.subject | Oxidative stress | en |
dc.subject | Glutathione | - |
dc.subject | Oxidation reduction | - |
dc.subject | Glutathione reductase | - |
dc.subject | Mortality | - |
dc.title | Plasma glutathione reductase activity and prognosis of septic shock | en |
dc.title.alternative | 26316444 | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김재성 | - |
dc.contributor.AlternativeAuthor | 권운용 | - |
dc.contributor.AlternativeAuthor | 서길준 | - |
dc.contributor.AlternativeAuthor | 김경수 | - |
dc.contributor.AlternativeAuthor | 정윤선 | - |
dc.contributor.AlternativeAuthor | 김성희 | - |
dc.contributor.AlternativeAuthor | 이소은 | - |
dc.identifier.doi | 10.1016/j.jss.2015.07.044 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:220162008006599001 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079751 | - |
dc.description.srnd | CITE_RATE:2.198 | - |
dc.description.srnd | FILENAME:2015_plasma gr activity and prognosis of septic shock.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:kwy711@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/a048b92c-e254-4f1d-bfb5-64bf6f122b1b/link | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 220162008006599001 | - |
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