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Prognostication of cardiac arrest survivors using low apparent diffusion coefficient cluster volume
DC Field | Value | Language |
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dc.contributor.author | Kim, Joonghee | en |
dc.contributor.author | Kim, Joonghee | - |
dc.contributor.author | Kim, Kyuseok | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kwon, Woon Yong | - |
dc.contributor.author | Shin, Jonghwan | - |
dc.contributor.author | Lee, Huijai | - |
dc.contributor.author | Choi, Sang-Cheon | - |
dc.contributor.author | Yun, Il Dong | - |
dc.contributor.author | Choi, Byung Se | - |
dc.contributor.author | Jung, Cheolkyu | - |
dc.contributor.author | Jo, You Hwan | - |
dc.contributor.author | Kim, Taeyun | - |
dc.contributor.author | Lee, Jae Hyuk | - |
dc.contributor.author | Kim, Yu jin | - |
dc.contributor.author | Ha, Chulmin | - |
dc.contributor.author | Kim, Kyung Su | - |
dc.date.accessioned | 2017-04-19T00:45:49Z | - |
dc.date.available | 2017-12-05T15:53:38Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | Resuscitation, Vol.100, pp. 18-24 | - |
dc.identifier.issn | 0300-9572 | - |
dc.identifier.uri | https://hdl.handle.net/10371/116925 | - |
dc.description.abstract | Introduction
We developed a new neuroprognostication method for cardiac arrest (CA) using the relative volume of the most dominant cluster of low apparent diffusion coefficient (ADC) voxels and tested its performance in a multicenter setting. Methods Adult (>15 years) out-of-hospital CA patients from three different facilities who underwent an MRI 12 h after resuscitation were retrospectively analyzed. Patients with unknown long-term prognosis or poor baseline neurologic function were excluded. Average ADCs (mean and median), LADCV (relative volume of low-ADC voxels) and DC-LADCV (relative volume of most dominant cluster of low-ADC voxels) were extracted using different thresholds between 400 and 800 × 10−6 mm2 s−1 at 10 × 10−6 mm2 s−1 intervals. Area under the receiver operating characteristic curve (AUROC) and sensitivity for poor outcome (6-month cerebral performance category score >2) while maintaining 100% specificity were measured. Results 110 patients were analyzed. Average ADCs showed fair performance with an AUROC of 0.822 (95% confidence interval [CI], 0.744–0.900) for the mean and 0.799 (95% CI, 0.716–0.882) for the median. LADCV showed better performance with a higher AUROC (maximum, 0.925) in an ADC threshold range of 400 to 690 × 10−6 mm2 s−1. DC-LADCV showed the best performance with a higher AUROC (maximum, 0.955) compared with LADCV in an ADC threshold range of 600 to 680 × 10−6 mm2 s−1. DC-LADCV had a high sensitivity for poor outcomes (>80%) in a wide threshold range from 400 to 580 × 10−6 mm2 s−1 with a maximum of 89.2%. Conclusions Quantitative analysis using DC-LADCV showed impressive performance in determining the prognosis of out-of-hospital CA patients in a multicenter setting. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | en |
dc.subject | Prognostication of cardiac arrest survivors using low apparent diffusion coefficient cluster volume | en |
dc.subject | 의약학 | en |
dc.subject | Cardiac arrest | - |
dc.subject | Brain ischemia | - |
dc.subject | Coma | - |
dc.subject | Magnetic resonance imaging | - |
dc.subject | Prognosis | - |
dc.subject | Computer-assisted image analyses | - |
dc.title | Prognostication of cardiac arrest survivors using low apparent diffusion coefficient cluster volume | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김중희 | - |
dc.contributor.AlternativeAuthor | 김규석 | - |
dc.contributor.AlternativeAuthor | 서길준 | - |
dc.contributor.AlternativeAuthor | 권운용 | - |
dc.contributor.AlternativeAuthor | 김경수 | - |
dc.contributor.AlternativeAuthor | 신종환 | - |
dc.contributor.AlternativeAuthor | 이희재 | - |
dc.contributor.AlternativeAuthor | 최상천 | - |
dc.contributor.AlternativeAuthor | 윤일동 | - |
dc.contributor.AlternativeAuthor | 최병세 | - |
dc.contributor.AlternativeAuthor | 정철규 | - |
dc.contributor.AlternativeAuthor | 조유환 | - |
dc.contributor.AlternativeAuthor | 김태윤 | - |
dc.contributor.AlternativeAuthor | 이재혁 | - |
dc.contributor.AlternativeAuthor | 김유진 | - |
dc.contributor.AlternativeAuthor | 하철민 | - |
dc.identifier.doi | 10.1016/j.resuscitation.2015.12.013 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:220162014020983001 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A080158 | - |
dc.description.srnd | CITE_RATE:5.414 | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:skycpr@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 220162014020983001 | - |
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